(1H,1H,2H,2H-十七氟癸基)膦酸 | 80220-63-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: (1H,1H,2H,2H-十七氟癸基)膦酸
• 中文别名: (1H,1H,2H,2H-全氟癸基)膦酸
• 英文名称: 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylphosphonic acid
• 英文别名: 1-phosphono-1H,1H,2H,2H-perfluorodecane
• CAS: 80220-63-9
• 化学式: C₁₀H₆F₁₇O₃P
• 分子量: 528.102
• InChiKey: CETXMCMQEXPPLV-UHFFFAOYSA-N

物化性质

• 熔点：
  180.0 to 184.0 °C
• 沸点：
  300.5±52.0 °C(Predicted)
• 密度：
  1.727±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  20

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

反应信息

• 作为产物：
  描述：

  diethyl 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylphosphonate 在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 30.0h， 生成 (1H,1H,2H,2H-十七氟癸基)膦酸
  参考文献：
  名称：

  氧化铝涂层玻璃载玻片上的聚糖阵列通过膦酸盐化学

  摘要：

  一种新型聚糖阵列共价或非共价连接到氧化铝涂层玻璃 (ACG) 载玻片上，已被开发用于酶促反应和蛋白质结合的研究。为了准备非共价阵列，带有多氟烃 (-C(8)F(17)) 尾部的聚糖被自动点到 ACG 滑动表面上，其中包含一层以膦酸盐结尾的多氟烃。孵育和洗涤后，非共价阵列可以通过 MS-TOF 在低激光能量下通过电离/解吸进行表征，而无需添加基质。开发了具有代表性的纤维四糖阵列来研究不同纤维素酶的活性和特异性，并区分外切和内切葡聚糖酶的活性。为了准备共价阵列，带有膦酸尾的聚糖被合成并自动点在 ACG 载玻片表面上。孵育后，载玻片可直接用于定量蛋白质结合分析。与在载玻片和其他表面上制备聚糖阵列相比，这种使用膦酸与 ACG 反应的阵列方法更直接、方便和有效，代表了蛋白质-聚糖相互作用的高通量分析的新平台。

  DOI：

  10.1021/ja1046523

文献信息

• [EN] FLUORINATED PHOSPHONIC ACIDS<br/>[FR] ACIDES PHOSPHONIQUES FLUORES
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2003102003A1

  公开（公告）日：2003-12-11

  Fluorinated phosphonic acid compounds, useful as treatments for substrate surfaces, have the formula (I) : wherein: R1 is a straight chain alkylene group having from 3 to 21 carbon atoms, an oxa-substituted straight chain alkylene group having from 2 to 20 carbon atoms, or a thia-substituted straight chain alkylene group having from 2 to 20 carbon atoms; R2 is a perfluoroalkyl group having from 4 to 10 carbon atoms; R3 is hydrogen, an alkali metal cation, or an alkyl group having from 1 to 6 carbon atoms; and M is hydrogen or an alkali metal cation, with the proviso that if R1 is an unsubstituted straight chain alkylene group, then the sum of carbon atoms in R1 and R2 combined is at least 10.

  氟磷酸化合物，用作处理基板表面的药物，其化学式为（I）：其中：R1为具有3至21个碳原子的直链烷基基团，具有2至20个碳原子的氧代取代直链烷基基团，或具有2至20个碳原子的硫代取代直链烷基基团；R2为具有4至10个碳原子的全氟烷基基团；R3为氢、碱金属阳离子，或具有1至6个碳原子的烷基基团；M为氢或碱金属阳离子，但如果R1为未取代的直链烷基基团，则R1和R2中碳原子的总和至少为10。
• Fluorinated phosphonic acids
  申请人：3M Innovative Properties Company

  公开号：US20030228469A1

  公开（公告）日：2003-12-11

  Fluorinated phosphonic acid compounds, useful as treatments for substrate surfaces, have the formula: 1 wherein: R 1 is a straight chain alkylene group having from about 3 to about 21 carbon atoms, an oxa-substituted straight chain alkylene group having from about 2 to about 20 carbon atoms, or a thia-substituted straight chain alkylene group having from about 2 to about 20 carbon atoms; R 2 is a perfluoroalkyl group having from about 4 to about 10 carbon atoms; R 3 is hydrogen, an alkali metal cation, or an alkyl group having from about 1 to about 6 carbon atoms; and M is hydrogen or an alkali metal cation, with the proviso that if R 1 is an unsubstituted straight chain alkylene group, then the sum of carbon atoms in R 1 and R 2 combined is at least 10.

  氟磷酸化合物可作为基底表面处理剂，其化学式为：1其中：R1是直链烷基，其碳原子数约为3到21个，氧代取代的直链烷基，其碳原子数约为2到20个，或硫代取代的直链烷基，其碳原子数约为2到20个；R2是全氟烷基，其碳原子数约为4到10个；R3是氢、一种碱金属阳离子或一个碳原子数约为1到6个的烷基；M是氢或一个碱金属阳离子，但如果R1是未取代的直链烷基，则R1和R2的碳原子数之和至少为10。
• GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS
  申请人：Wong Chi-Huey

  公开号：US20100016171A1

  公开（公告）日：2010-01-21

  Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.

  铝涂层玻璃载玻片提供了一种新的糖基阵列平台。具体而言，铝涂层玻璃载玻片增加了荧光基础检测方法的灵敏度。此外，铝涂层玻璃载玻片允许对碳水化合物进行质谱分析，并提供了检查纤维素酶活性的平台。ACG载玻片的独特性质包括：1）表面的金属氧化物层可以被激活，以嫁接有机化合物，如修饰的寡糖；2）表面仍然具有电导性，嫁接的寡糖可以同时通过质谱分析和糖类结合分析进行表征；3）与透明玻璃载玻片相比，这些载玻片在结合分析中更为敏感。
• TRANSPARENT SELF-HEALING OMNIPHOBIC COATINGS
  申请人：Nbd Nanotechnologies, Inc.

  公开号：EP3167964A1

  公开（公告）日：2017-05-17

  Processes for preparing oleophobic and hydrophobic coatings on a substrate. More particularly, the disclosure relates to omniphobic surface treatment of substrates such as glass, ceramic, glass-ceramic, and the like.

  在基材上制备疏油和疏水涂层的工艺。更具体地说，本公开涉及玻璃、陶瓷、玻璃陶瓷等基材的全疏表面处理。
• COMPOSITION FOR IMPREGNATING A SUBSTRATE, IN PARTICULAR A WATCHSTRAP
  申请人：Rolex S.A.

  公开号：EP3744175A1

  公开（公告）日：2020-12-02

  A composition for impregnating a watchstrap or parts thereof is disclosed, the composition comprising a) an organic solvent or a sol-gel, b) at least one active organic compound comprising, preferably consisting of, a phosphonate group -PO3H and an hydrophobic or hyper-hydrophobic group, and c) optionally one or more functional groups selected from i. an antifouling functional group and ii. a bioactive functional group, Further, two processes for functionalizing a watchstrap or parts thereof are disclosed, one comprising impregnating a watchstrap or parts thereof with the composition containing the organic solvent, the second comprising impregnating a watchstrap or parts thereof with a silica sol-gel solution, which optionally comprises at least one active organic molecule as defined above.

  公开了一种用于浸渍表带或其部件的组合物，该组合物包括 a) 有机溶剂或溶胶凝胶、 b) 至少一种活性有机化合物，最好包括一个膦酸基 -PO3H 和一个疏水或超疏水基团，以及 c) 可选的一个或多个官能团，选自 防污官能团和 ii. 生物活性官能团、 此外，还公开了两种使表带或其部件功能化的工艺，其中一种包括用含有有机溶剂的组合物浸渍表带或其部件，第二种包括用二氧化硅溶胶-凝胶溶液浸渍表带或其部件，该溶液可选择包含至少一种如上定义的活性有机分子。