(1R,2R)-2-苯基环丙胺 | 69684-88-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (1R,2R)-2-苯基环丙胺
• 英文名称: cis-2-Phenylcyclopropylamin
• 英文别名: (1R,2R)-(-)-2-phenylcyclopropyl-1-amine；(-)-2-phenylcyclopropyl-1-amine；(1R,2R)-(-)-cPCPA；cis-2-Phenylcyclopropylamine；(1R,2R)-2-phenylcyclopropan-1-amine
• CAS: 69684-88-4
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: AELCINSCMGFISI-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1R,2R)-2-苯基环丙胺 以10%的产率得到
  参考文献：
  名称：

  BORNE R. F.; FORRESTER M. L.; WATERS I. W., J. MED. CHEM. , 1977, 20, NO 6, 771-776

  摘要：

  DOI：
• 作为产物：
  描述：

  (1R,2R)-trans-2-phenyl-1-cyclopropanecarboxylic acid 以7%的产率得到
  参考文献：
  名称：

  BORNE R. F.; FORRESTER M. L.; WATERS I. W., J. MED. CHEM. , 1977, 20, NO 6, 771-776

  摘要：

  DOI：

文献信息

• [EN] APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS<br/>[FR] INHIBITEURS DE KINASE 1 DE RÉGULATION DE SIGNAL D'APOPTOSE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009123986A1

  公开（公告）日：2009-10-08

  The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  本发明涉及具有以下结构的凋亡信号调节激酶1（"ASK1"）抑制化合物（I）；其中变量如本文所定义。该发明还涉及包含这些化合物的药物组合物、试剂盒和制造品；用于制备这些化合物的有用中间体和方法；以及使用这些化合物的方法。
• Substituted pteridines for the treatment of inflammatory diseases
  申请人：Dollinger Horst

  公开号：US20060116370A1

  公开（公告）日：2006-06-01

  The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

  这项发明涉及新的蕨类素，适用于治疗呼吸道或消化系统的疾病或不适，关节、皮肤或眼睛的炎症性疾病，外周或中枢神经系统的疾病或癌症，以及含有这些化合物的药物组合物。
• Method for inhibition of HIV related viruses
  申请人：Medivir AB

  公开号：US05593993A1

  公开（公告）日：1997-01-14

  Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.

  本发明揭示了使用硫脲衍生物化合物或其盐治疗艾滋病，抑制HIV及其相关病毒的复制，以及使用这些化合物的配方。此外，还揭示了新的硫脲衍生物化合物。
• Compounds and methods for inhibition of HIV and related viruses
  申请人：Medivir A/B

  公开号：US05658907A1

  公开（公告）日：1997-08-19

  Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.

  本文介绍了治疗艾滋病、抑制HIV及其相关病毒复制以及使用硫脲衍生物化合物或其盐的制剂。同时，还介绍了新型的硫脲衍生物化合物。
• TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2
  申请人：Minucci Saverio

  公开号：US20130035377A1

  公开（公告）日：2013-02-07

  Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R 3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.

  Tranylcypromine衍生物可用作治疗剂，特别是用于预防和/或治疗与组蛋白去甲基化酶LSD1和LSD2活性相关的疾病和病况，例如由基因转录、细胞分化和增殖失调所特征的疾病，如肿瘤、病毒感染等。这些化合物属于结构式（I），其中A和R3的定义如规范所述。本发明还涉及这些化合物的制备，以及含有它们的组合物和其治疗用途。