(2-嘧啶基氨基)甲醇 | 89179-59-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (2-嘧啶基氨基)甲醇
• 英文名称: N-hydroxymethyl-2-aminopyrimidine
• 英文别名: N-(Pyrimidin-2-yl)-aminomethanol；pyrimidin-2-ylamino-methanol；(Pyrimidin-2-ylamino)methanol
• CAS: 89179-59-9
• 化学式: C₅H₇N₃O
• 分子量: 125.13
• InChiKey: BXAJLEOBEHYFTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3,5-三嗪-2,4,6-三胺,N,N'''-1,2-乙二基二[N-[3-[[4,6-二[丁基(2,2,6,6-四甲基-4-哌啶基)氨基]-1,3,5-三嗪-2-基]氨基]丙基]-N,N''-二丁基-N,N''-二(2,2,6,6-四甲基-4-哌啶基)- 、 聚合甲醛 以 甲苯 为溶剂， 反应 1.0h， 以82%的产率得到(2-嘧啶基氨基)甲醇
  参考文献：
  名称：

  Heteroaromatic primary amines and formaldehyde: The formation of N-hydroxymethyl derivatives

  摘要：

  A product study of the reaction of three heteroaromatic primary amines with paraformaldehyde was made: N-hydroxymethylamines were identified in all cases. Two of them yielded also N,N-dihydroxymethyl derivatives. X-Ray diffraction structure determination on one of the N-hydroxymethyl derivatives ruled out the presence of internal hydrogen bonding in the solid state, notwithstanding the almost ideally planar arrangement of the aromatic moiety and the amino function.

  DOI：

  10.1016/0040-4020(95)00442-b

文献信息

• Heteroaromatic primary amines and formaldehyde: The formation of N-hydroxymethyl derivatives
  作者：Giancarlo Verardo、Fausto Gorassini、Angelo G. Giumanini、Tiziano Scubla、Marilena Tolazzi、Paolo Strazzolini

  DOI：10.1016/0040-4020(95)00442-b

  日期：1995.7

  A product study of the reaction of three heteroaromatic primary amines with paraformaldehyde was made: N-hydroxymethylamines were identified in all cases. Two of them yielded also N,N-dihydroxymethyl derivatives. X-Ray diffraction structure determination on one of the N-hydroxymethyl derivatives ruled out the presence of internal hydrogen bonding in the solid state, notwithstanding the almost ideally planar arrangement of the aromatic moiety and the amino function.