山嵛酰胺MEA | 94109-05-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 山嵛酰胺MEA
• 英文名称: N-(2-hydroxyethyl)docosanamide
• 英文别名: N-lauroylethanolamine
• CAS: 94109-05-4
• 化学式: C₂₄H₄₉NO₂
• 分子量: 383.659
• InChiKey: XHFWUECSNJWBJU-UHFFFAOYSA-N

物化性质

• 熔点：
  102-104 °C(Solv: water (7732-18-5))
• 沸点：
  533.4±33.0 °C(Predicted)
• 密度：
  0.896±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿：0.3mg/mL
• LogP：
  8.853 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  27
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  水 、 山嵛酰胺MEA 生成 Behenate 、 2-amino-ethanol; protonated form
  参考文献：
  名称：

  Assignment of Endogenous Substrates to Enzymes by Global Metabolite Profiling

  摘要：

  Enzymes regulate biological processes through the conversion of specific substrates to products. Therefore, of fundamental interest for every enzyme is the elucidation of its natural substrates. Here, we describe a general strategy for identifying endogenous substrates of enzymes by untargeted liquid chromatography-mass spectrometry (LC-MS) analysis of tissue metabolomes from wild-type and enzyme-inactivated organisms. We use this method to discover several brain lipids regulated by the mammalian enzyme fatty acid amide hydrolase (FAAH) in vivo, including known signaling molecules (e.g., the endogenous cannabinoid anandamide) and a novel family of nervous system-enriched natural products, the taurine-conjugated fatty acids. Remarkably, the relative hydrolytic activity that FAAH exhibited for lipid metabolites in vitro was not predictive of the identity of specific FAAH substrates in vivo. Thus, global metabolite profiling establishes unanticipated connections between the proteome and metabolome that enable assignment of an enzyme's unique biochemical functions in vivo.

  DOI：

  10.1021/bi0480335
• 作为产物：
  描述：

  、 C.I.酸性橙108 以 二氯甲烷 为溶剂， 生成 山嵛酰胺MEA
  参考文献：
  名称：

  N-(2-羟基-乙基)酰胺衍生物的合成及抗惊厥活性

  摘要：

  合成了一系列新型 N-(2-羟乙基)酰胺衍生物，并通过最大电休克 (MES) 试验筛选其抗惊厥活性，并通过旋转棒试验 (Tox) 评估其神经毒性。最大电休克试验表明，N-（2-羟乙基）癸酰胺 1g、N-（2-羟乙基）棕榈酰胺 1l 和 N-（2-羟乙基）硬脂酰胺 1n 显示出更好的抗惊厥活性，并且具有更低的抗惊厥活性。毒性比标记的抗癫痫药丙戊酸盐要低。在抗 MES 效力测试中，这些化合物的中位有效剂量 (ED50) 分别为 22.0、23.3、20.5 mg/kg，中位毒性剂量 (TD50) 分别为 599.8、>1000、>1000 mg/kg，导致保护指数 (PI) 分别为 27.5、>42.9、>48.8。这是比标记的抗癫痫药物丙戊酸盐（PI = 1.6）更好的保护指数。为了进一步研究几种不同模型中抗惊厥活性的影响，测试了化合物 1g、1l 和 1n 引起的惊厥，这些化学物质包括戊四

  DOI：

  10.1002/ardp.200800153

文献信息

• Liquid detergent composition
  申请人：KAO CORPORATION

  公开号：EP0535693A1

  公开（公告）日：1993-04-07

  This invention provides a liquid detergent composition comprising (A) a surface active agent, (B) a pearlescent agent, and (C) a viscosity modifier, which exhibits an opaque appearance and has a viscosity of 200-4,000 cps at 20°C bulk temperature and a Brookfield yield value of 5-100 p. This detergent composition can be squeezed from a container at a constant volume and can be perceived visually when applied onto a sponge without being soaked quickly into it so that it is not only economical since it prevents excess usage but also helps to prevent chapped hands or skin roughening.

  本发明提供了一种液体洗涤剂组合物，该组合物由(A)表面活性剂、(B)珠光剂和 (C)粘度调节剂组成，其外观不透明，在 20°C 散装温度下粘度为 200-4000 cps，布鲁克菲尔德屈服值为 5-100 p。 这种洗涤剂组合物可以以恒定的体积从容器中挤出，涂抹在海绵上时可以直观地感觉到，不会很快浸入海绵中，因此不仅经济实惠，因为它可以防止过量使用，还有助于防止手部皲裂或皮肤粗糙。
• Preparation method for shear-thinning water-based ball-point pen inks, shear-thinning water-based ball-point pen ink compositions, and ball-point pens employing the same
  申请人：The Pilot Ink CO., Ltd.

  公开号：EP0787779A2

  公开（公告）日：1997-08-06

  A shear-thinning water-based ball-point pen ink composition comprising from 1% by weight to 35% by weight of a colorant, from 2% by weight to 35% by weight of a water-soluble polar solvent, from 1% by weight to 30% by weight of a nonionic surface active agent having an HLB value within the range of from 8 to 12, and the balance being water and adjusting additives, and having a viscosity within the range of from 25 mPa.s to 160 mPa.s (a value at the number of revolution of 100 rpm in an EM type rotational viscometer, 25°C) and a shear thinning index within the range of from 0.1 to 0.6; the nonionic surface active agent having a mixed phase comprising a phase standing dispersed in the form of fine particles and a phase standing dissolved in a molecular state. A method for preparing the ink composition and a ball-point pen employing the ink composition are also disclosed.

  一种剪切稀化型水基圆珠笔墨水组合物，包括重量百分比为 1%至 35%的着色剂、重量百分比为 2%至 35%的水溶性极性溶剂、重量百分比为 1%至 30%的 HLB 值在 8 至 12 范围内的非离子表面活性剂，余量为水和调节添加剂。s至 160 mPa.s（在 EM 型旋转粘度计中，转速为 100 rpm，温度为 25℃时的值），剪切稀化指数在 0.1 至 0.6 之间；非离子表面活性剂具有混合相，混合相包括以细颗粒形式分散的相和以分子状态溶解的相。 此外，还公开了制备该墨水组合物的方法和使用该墨水组合物的圆珠笔。
• MODIFIED OLEFIN (CO)POLYMER COMPOSITION, PROCESS FOR PREPARING THE SAME, AND MODIFIED OLEFIN (CO)POLYMER COMPOSITION MOLDING
  申请人：CHISSO CORPORATION

  公开号：EP0972800A1

  公开（公告）日：2000-01-19

  A high molecular weight polyethylene prepared by preliminary polymerization is added at the time of main polymerization of an olefin, for example, propylene, to prepare an olefin (co)polymer composition comprising the above high molecular weight polyethylene finely dispersed as fine particles in the polyolefin, such as polypropylene, and a cross-linked structure is formed in the olefin (co)polymer composition. This process can provide a modified olefin (co)polymer composition improved in the strength in a molten state in terms of melt tension or the like and in crystallization temperature and excellent in moldability such as high-speed producibility and a molded modified olefin (co)polymer composition excellent in properties such as heat resistance and rigidity.

  在对烯烃（例如丙烯）进行主聚合时，加入通过预聚合制备的高分子量聚乙烯，以制备烯烃（共）聚合物组合物，该组合物由上述高分子量聚乙烯以细颗粒形式分散在聚烯烃（例如聚丙烯）中组成，并在烯烃（共）聚合物组合物中形成交联结构。这种工艺可以提供一种改性烯烃（共）聚合物组合物，它在熔融状态下的强度（如熔体张力等）和结晶温度方面都有所提高，并具有优异的成型性（如高速生产性），而且成型的改性烯烃（共）聚合物组合物具有优异的性能（如耐热性和刚性）。
• Conditioning cream color base having good color deposition properties.
  申请人：L'Oréal

  公开号：EP1852103A2

  公开（公告）日：2007-11-07

  The present invention is directed to a process and composition for dyeing hair, the composition containing:(a) greater than 10% by weight, based on the weight of the composition, of at least one fatty acid alkanolamide;(b) at least one C6-C36 dicarboxylic acid;(c) at least one water soluble base capable of reacting with the at least one C6-C36 dicarboxylic acid (b) to form a soap;(d) at least one conditioning polymer; (e) at least one oxidation dye; and(f) optionally, at least one oxidizing agent, wherein the composition is in cream form.

  本发明涉及一种染发工艺和组合物，该组合物含有(a) 至少一种脂肪酸烷醇酰胺；(b) 至少一种 C6-C36 二羧酸；(c) 至少一种能与至少一种 C6-C36 二羧酸 (b) 反应形成皂的水溶性碱；(d) 至少一种调理聚合物；(e) 至少一种氧化染料；以及(f) 可选地，至少一种氧化剂，其中该组合物为膏状。
• LUBRICATING OIL COMPOSITION, AND SLIDING MECHANISM USING LUBRICATING OIL COMPOSITION
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP2826844A1

  公开（公告）日：2015-01-21

  Disclosed is a lubricating oil composition for low-friction sliding materials, which is used in a sliding mechanism where a DLC film containing hydrogen in an amount of from 5 atom% to 50 atom% is formed on at least one sliding surface. The lubricating oil composition contains, in the lubricant base oil therein and based on the total amount of the composition, (A) an organic zinc dithiophosphate in an amount of from 0.005% by mass to 0.12% by mass in terms of the phosphorus concentration therein, (B) an amide-based friction-reducing agent in an amount of from 0.05% by mass to 5.0% by mass, and (C) an alkaline earth metal salicylate-based detergent and/or an alkaline earth metal sulfonate-based detergent in an amount of from 0.05% by mass to 0.5o by mass in terms of the alkaline earth metal concentration therein.

  本发明公开了一种用于低摩擦滑动材料的润滑油组合物，该组合物用于在至少一个滑动表面上形成含氢量为 5 原子％至 50 原子％的 DLC 膜的滑动机构中。 该润滑油组合物在其中的润滑油基础油中，根据组合物的总量，含有 (A) 有机二硫代磷酸锌，以其中的磷浓度计，含量为 0.005% （质量分数）至 0.12% （质量分数）；(B) 酰胺基减摩剂，含量为 0.05% (质量)至 5.0% (质量)，以及 (C) 碱土金属水杨酸酯类洗涤剂和/或碱土金属磺酸盐类洗涤剂，以其中碱土金属浓度计，用量为 0.05% (质量)至 0.5o (质量)。