1,2-Distearyl-sn-glycero-3-phosphoethanolamine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-Distearyl-sn-glycero-3-phosphoethanolamine
• 英文别名: 2-aminoethyl [(2R)-2,3-dioctadecoxypropyl] hydrogen phosphate
• 化学式: C₄₁H₈₆NO₆P
• 分子量: 720.1
• InChiKey: GGZUDCAITXWZKO-VQJSHJPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.2
• 重原子数：
  49
• 可旋转键数：
  43
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• FUNCTIONAL WOUND DRESSING
  申请人：Paul Hartmann AG

  公开号：EP3569261A1

  公开（公告）日：2019-11-20

  The invention relates to a functional wound dressing being able to detect and indicate the state of the wound, in particular with regard to infections for example caused by toxins produced by bacteria such Staphylococcus aureus and Pseudomonas aeruginosa. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

  本发明涉及一种功能性伤口敷料，它能够检测和显示伤口的状态，尤其是由金黄色葡萄球菌和绿脓杆菌等细菌产生的毒素引起的感染。本伤口敷料可用于湿性伤口愈合，含有一种能够吸收伤口渗出物并为伤口提供水分的物质。
• METHOD OF TREATMENT OF INFECTED TISSUES
  申请人：LIPOSOME TECHNOLOGY, INC.

  公开号：EP0632719A1

  公开（公告）日：1995-01-11
• POLYAMIDE OLIGOMERS
  申请人：INEX Pharmaceuticals Corp.

  公开号：EP1041976B1

  公开（公告）日：2006-04-05
• PEPTIDE LIGAND DIRECTED DRUG DELIVERY
  申请人：Shanghai Jiaotong University

  公开号：EP2215107B1

  公开（公告）日：2012-10-17
• LIPOSOMAL FORMULATIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US20160193148A1

  公开（公告）日：2016-07-07

  The present disclosure relates to liposomal formulations of aminoglycoside such as gentamicin, the method of making and method of using such formulations. The aminoglycoside liposomal formulations disclosed have higher drug to lipid loading ratio, and enable the formulations to be used to treat infections caused by bacterial species resistant to common antibiotics. In one embodiment, a gentamicin liposome formulation with a gentamicin to phospholipid ratio of 10:1 to 26:1 has been prepared and shown to be effective at treating infections caused by R. equi.