(2R)-1-(1-甲基-1H-咪唑-4-基)-2-丙胺 | 736115-18-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (2R)-1-(1-甲基-1H-咪唑-4-基)-2-丙胺
• 英文名称: N-tele-(R)α-Dimethylhistamine
• 英文别名: (R)-N(tele),α-dimethylhistamine；(R)-1-(1-Methyl-1H-imidazol-4-YL)propan-2-amine；(2R)-1-(1-methylimidazol-4-yl)propan-2-amine
• CAS: 736115-18-7
• 化学式: C₇H₁₃N₃
• 分子量: 139.2
• InChiKey: HMKKPVLTZFFRFB-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R)-1-(1-甲基-1H-咪唑-4-基)-2-丙胺 、 4-溴苯磺酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 15.0h， 以43%的产率得到(R)-4-bromo-N-[1-methyl-2-(1-methyl-1H-imidazol-4-yl)ethyl]benzenesulfonamide
  参考文献：
  名称：

  Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization

  摘要：

  An ultra-performance liquid chromatography tandem mass spectrometry (UPLC (TM)-MS/MS) assay was developed for the simultaneous analysis of histamine, its major metabolite tele-methylhistamine, and an internal standard (N-tele-(R)-alpha-dimethylhistamine) from human cerebrospinal fluid (CSF) samples. The method involves derivatization of primary amines with 4-bromobenzenesulfonyl chloride and subsequent analysis by reversed phase liquid chromatography with mass spectrometry detection and positive electrospray ionization. The separation of derivatized biogenic amines was achieved within 3.5 min on an Acquity (R) BEH C-18 column by elution with a linear gradient of acetonitrile/water/formic acid (0.1%). The assay was linear in the concentration range of 50-5000 pM for each amine (5.5-555 pg/ml for histamine and 6.25-625 pg/ml for tele-methylhistamine). For repeatability and precision determination, coefficients of variation (CVs) were less than 11.0% over the tested concentration ranges, within acceptance criteria. Thus, the developed method provides the rapid, easy, highly sensitive, and selective requirement to quantify these amines in human CSF. No significant difference was found in the mean +/- standard error levels of these amines between a group of narcoleptic patients (histamine = 392 +/- 64 pM, tele-methylhistamine = 2431 +/- 461 pM, n = 7) and of neurological control subjects (histamine = 402 +/- 72 pM, tele-methylhistamine = 2209 +/- 463 pM, n = 32). (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.ab.2010.09.045

文献信息

• Hepatitis C Virus Inhibitors
  申请人：Bachand Carol

  公开号：US20090202478A1

  公开（公告）日：2009-08-13

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和用于治疗丙型肝炎病毒（HCV）感染的方法。还公开了含有这些化合物的药物组合物以及在治疗HCV感染中使用这些化合物的方法。
• HEPATITIS C VIRUS INHIBITORS
  申请人：Bachand Carol

  公开号：US20080299075A1

  公开（公告）日：2008-12-04

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和用于治疗丙型肝炎病毒（HCV）感染的方法。还公开了含有这些化合物的制药组合物和使用这些化合物治疗HCV感染的方法。
• MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS
  申请人：Seattle Genetics, Inc.

  公开号：US20130123465A1

  公开（公告）日：2013-05-16

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供了MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类类似物，其具有C-末端苯丙氨酸残基侧链替换或修饰，可单独提供或通过各种连接剂连接到配体上。相关的结合物可以定向特定的细胞类型，以提供治疗效益。
• Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus
  申请人：Seattle Genetics, Inc.

  公开号：US10000555B2

  公开（公告）日：2018-06-19

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供的 MeVal-Val-Dil-Dap-Phe (MMAF) Auristatin 肽类似物具有 C 端苯丙氨酸残基侧链替换或修饰，可单独提供或通过各种连接体连接到配体上。相关共轭物可靶向特定细胞类型，提供治疗效果。
• US7745636B2
  申请人：——

  公开号：US7745636B2

  公开（公告）日：2010-06-29