(2R)-2-({6-[(3-氨基-5-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基}氨基)-3-甲基-1-丁醇 | 220792-57-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: (2R)-2-({6-[(3-氨基-5-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基}氨基)-3-甲基-1-丁醇
• 英文名称: aminopurvalanol A
• 英文别名: (2R)-2-[[6-(3-amino-5-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
• CAS: 220792-57-4
• 化学式: C₁₉H₂₆ClN₇O
• 分子量: 403.9
• InChiKey: RAMROQQYRRQPDL-HNNXBMFYSA-N

物化性质

• 沸点：
  639.0±65.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)
• 溶解度：
  在 DMSO 中溶解度为 100 mM

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  7

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

文献信息

• Methods for making pancreatic endocrine cells
  申请人：Janssen Biotech, Inc.

  公开号：US10421948B2

  公开（公告）日：2019-09-24

  The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.

  本发明提供了一种提高表达胰腺内分泌系特征标记的细胞中 MAFA 表达量的方法，该方法包括以下步骤：在含有足量细胞周期蛋白依赖性激酶抑制剂的培养基中培养表达胰腺内分泌系特征标记的细胞，以引起 MAFA 表达量的增加。
• DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE
  申请人：Centocor Ortho Biotech Inc.

  公开号：EP2346988A1

  公开（公告）日：2011-07-27
• Differentiation of Human Embryonic Stem Cells
  申请人：Rezania Alireza

  公开号：US20100112693A1

  公开（公告）日：2010-05-06

  The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA.
• Method for the treatment of amyloidoses
  申请人：Nimmrich Volker

  公开号：US20100311767A1

  公开（公告）日：2010-12-09

  The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an agonist of the P/Q type voltage-gated presynaptic calcium channel to said subject.
• Differentiation of Human Pluripotent Stem Cells
  申请人：Janssen Biotech, Inc.

  公开号：US20160160182A1

  公开（公告）日：2016-06-09

  The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.