(3,4-二氢萘-1-基)(4-甲氧基苯基)甲醇 | 863479-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: (3,4-二氢萘-1-基)(4-甲氧基苯基)甲醇
• 英文名称: (3,4-Dihydro-naphthalen-1-yl)-(4-methoxy-phenyl)-methanol
• 英文别名: 3,4-Dihydronaphthalen-1-yl-(4-methoxyphenyl)methanol；3,4-dihydronaphthalen-1-yl-(4-methoxyphenyl)methanol
• CAS: 863479-90-7
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.34
• InChiKey: AWXKFTMLIVTFQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3,4-二氢萘-1-基)(4-甲氧基苯基)甲醇 在 三溴化磷 作用下， 以 苯 为溶剂， 反应 0.08h， 以59%的产率得到1-(4-methoxybenzyl)naphthalene
  参考文献：
  名称：

  Convenient phosphorus tribromide induced syntheses of substituted 1-arylmethylnaphthalenes from 1-tetralone derivatives

  摘要：

  A series of 1-arylmethylnaphthalenes 7a-g and I I have been synthesized conveniently in good yields at room temperature through phosphorus tribromide induced aromatization of 1-aryl-[3,4]-dihydronaphthyl-methanols 6a-g and 10, which were obtained from 1-tetralone derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.016
• 作为产物：
  描述：

  4-溴-1,2-二氢萘 、 4-甲氧基苯甲醛 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以60%的产率得到(3,4-二氢萘-1-基)(4-甲氧基苯基)甲醇
  参考文献：
  名称：

  Convenient phosphorus tribromide induced syntheses of substituted 1-arylmethylnaphthalenes from 1-tetralone derivatives

  摘要：

  A series of 1-arylmethylnaphthalenes 7a-g and I I have been synthesized conveniently in good yields at room temperature through phosphorus tribromide induced aromatization of 1-aryl-[3,4]-dihydronaphthyl-methanols 6a-g and 10, which were obtained from 1-tetralone derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.016

文献信息

• Rhodium-Catalyzed Enantioselective Isomerization of Secondary Allylic Alcohols
  作者：Tang-Lin Liu、Teng Wei Ng、Yu Zhao

  DOI：10.1021/jacs.7b01096

  日期：2017.3.15

  The first catalytic enantioselective isomerization of secondary allylic alcohols to access ketones with a α-tertiary stereocenter is presented. The racemic allylic alcohol substrates can be converted to the enantioenriched ketone products in a stereoconvergent fashion. The use of commercially available catalysts and mild reaction conditions makes this an attractive method in stereoselective synthesis

  介绍了仲烯丙醇的第一个催化对映选择性异构化以获取具有 α-叔立体中心的酮。外消旋烯丙醇底物可以立体会聚方式转化为对映体富集的酮产物。使用市售催化剂和温和的反应条件使其成为立体选择性合成中的一种有吸引力的方法。
• Arylation and Vinylation of Alkenes Based on Unusual Sequential Semipinacol Rearrangement/Grob Fragmentation of Allylic Alcohols
  作者：Dao-Yi Yuan、Yong-Qiang Tu、Chun-An Fan

  DOI：10.1021/jo801434b

  日期：2008.10.3

  Alkenes can be stereoselectively arylated and vinylated without transition-metal catalyst under mild conditions through an interesting NBS-promoted semipinacol rearrangement and a subsequent unusual NaOH-mediated Grob fragmentation.

  通过有趣的NBS促进的半频哪醇重排以及随后的异常NaOH介导的Grob裂解，烯烃可以在温和的条件下进行立体选择性芳基化和乙烯基化，而无需使用过渡金属催化剂。
• Convenient phosphorus tribromide induced syntheses of substituted 1-arylmethylnaphthalenes from 1-tetralone derivatives
  作者：Shagufta、Resmi Raghunandan、Prakas R. Maulik、Gautam Panda

  DOI：10.1016/j.tetlet.2005.06.016

  日期：2005.8

  A series of 1-arylmethylnaphthalenes 7a-g and I I have been synthesized conveniently in good yields at room temperature through phosphorus tribromide induced aromatization of 1-aryl-[3,4]-dihydronaphthyl-methanols 6a-g and 10, which were obtained from 1-tetralone derivatives. (c) 2005 Elsevier Ltd. All rights reserved.