(3-(烯丙基(苯基)氨基)丙-1-烯-2-基)锂 | 190277-33-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (3-(烯丙基(苯基)氨基)丙-1-烯-2-基)锂
• CAS: 190277-33-9
• 化学式: C₁₂H₁₄LiN
• 分子量: 179.191
• InChiKey: AWBBDBOTQIRGMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-(烯丙基(苯基)氨基)丙-1-烯-2-基)锂 在 四甲基乙二胺 、 水 作用下， 以88%的产率得到N-(2-methylene-4-pentenyl)aniline
  参考文献：
  名称：

  Regio- and stereoselective copper-induced isomerization of 2-alkenyl 2-lithiophenyl ethers to 2-(2-alkenyl)phenols

  摘要：

  N-Allyl-N-(2-lithioallyl)aniline undergoes intramolecular carbometallation via 5-exo addition on treatment with CuCN. 2-Alkenyl 2-bromophenyl ethers rearrange to 2-(2-alkenyl)phenols by bromine-lithium exchange and further transmetallation with CuCN. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01379-8
• 作为产物：
  描述：

  N-allyl-N-(2-bromoallyl)aniline 在 叔丁基锂 作用下， 以 乙醚 为溶剂， 生成 (3-(烯丙基(苯基)氨基)丙-1-烯-2-基)锂
  参考文献：
  名称：

  5-exo versus 6-endo intramolecular carbolithiation of N-allyl-N-(2-lithioallyl)amines

  摘要：

  N-Allyl-N-(2-lithioallyl)amines undergo intramolecular carbometallation via 5-exo or 6-endo addition. The course of the reaction depends on the nitrogen electron density. 3-Functionalized-4-methylenepyrrolidines can be synthesized. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00465-6

文献信息

• Regio- and stereoselective copper-induced isomerization of 2-alkenyl 2-lithiophenyl ethers to 2-(2-alkenyl)phenols
  作者：José Barluenga、Roberto Sanz、Francisco J. Fañanás

  DOI：10.1016/s0040-4039(97)01379-8

  日期：1997.8

  N-Allyl-N-(2-lithioallyl)aniline undergoes intramolecular carbometallation via 5-exo addition on treatment with CuCN. 2-Alkenyl 2-bromophenyl ethers rearrange to 2-(2-alkenyl)phenols by bromine-lithium exchange and further transmetallation with CuCN. (C) 1997 Elsevier Science Ltd.
• 5-exo versus 6-endo intramolecular carbolithiation of N-allyl-N-(2-lithioallyl)amines
  作者：José Barluenga、Roberto Sanz、Francisco J. Fañanás

  DOI：10.1016/s0040-4039(97)00465-6

  日期：1997.4

  N-Allyl-N-(2-lithioallyl)amines undergo intramolecular carbometallation via 5-exo or 6-endo addition. The course of the reaction depends on the nitrogen electron density. 3-Functionalized-4-methylenepyrrolidines can be synthesized. (C) 1997 Published by Elsevier Science Ltd.