(3-异丙基-[2]萘基)-甲基醚 | 100883-22-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: (3-异丙基-[2]萘基)-甲基醚
• 英文名称: 3-isopropyl-2-methoxynaphthalene
• 英文别名: (3-isopropyl-[2]naphthyl)-methyl ether；(3-Isopropyl-[2]naphthyl)-methyl-aether；2-Methoxy-3-propan-2-ylnaphthalene
• CAS: 100883-22-5
• 化学式: C₁₄H₁₆O
• 分子量: 200.28
• InChiKey: FRUYCTREBIUZAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  117 °C(Press: 0.6 Torr)
• 密度：
  1.013±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-异丙基-[2]萘基)-甲基醚 在 三溴化硼 、 戴斯-马丁氧化剂 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 4-(p-Toluidino)-3-isopropylnaphthalene-1,2-dione
  参考文献：
  名称：

  Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

  摘要：

  Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.080
• 作为产物：
  描述：

  6-isopropyl-7-methoxy-1-tetralone 在 potassium hydrogensulfate 、 lithium aluminium tetrahydride 、 乙醚 、 sulfur 作用下， 生成 (3-异丙基-[2]萘基)-甲基醚
  参考文献：
  名称：

  Sengupta et al., Journal of the Indian Chemical Society, 1959, vol. 36, p. 659,665

  摘要：

  DOI：

文献信息

• ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
  申请人：Kineta Immuno-Oncology LLC

  公开号：US20200055871A1

  公开（公告）日：2020-02-20

  The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

  本发明涉及式（I）化合物，该化合物是RIG-I通路的激活剂。
• PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
  申请人：Gilead Sciences, Inc.

  公开号：US20130164280A1

  公开（公告）日：2013-06-27

  The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

  该发明提供了用于治疗病毒感染的化合物、药物可接受的盐和酯以及它们的组合物。这些化合物和组合物对于治疗包括人类呼吸道合胞病毒感染在内的肺病毒亚科病毒感染是有用的。
• [EN] ORGANIC COMPOUND, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE<br/>[FR] COMPOSÉ ORGANIQUE, ÉLÉMENT ÉLECTROLUMINESCENT, DISPOSITIF ÉLECTROLUMINESCENT, DISPOSITIF ÉLECTRONIQUE ET DISPOSITIF D'ÉCLAIRAGE
  申请人：SEMICONDUCTOR ENERGY LAB

  公开号：WO2018203171A1

  公开（公告）日：2018-11-08

  An organic compound has a benzonaphthofuran skeleton and is represented by Formula (G1). In Formula (G1), A represents a pyrene skeleton. In the case where the pyrene skeleton has a substituent, the substituent is a diarylamino group including two substituted or unsubstituted aryl groups each having 6 to 13 carbon atoms, a substituted or unsubstituted aryl group having 6 to 13 carbon atoms, an alkyl group having 1 to 7 carbon atoms, a substituted or unsubstituted monocyclic saturated hydrocarbon group having 3 to 20 carbon atoms, or a substituted or unsubstituted poly cyclic saturated hydrocarbon group having 7 to 10 carbon atoms. The two aryl groups of the diarylamino group may be the same or different. In X1 represented by Formula (G1-1), one of R6 and R7 is bonded to N in Formula (G1), and the other of R6 and R7 represents an alkyl group having 1 to 7 carbon atoms, a substituted or unsubstituted monocyclic saturated hydrocarbon group having 3 to 20 carbon atoms, or a substituted or unsubstituted poly cyclic saturated hydrocarbon group having 7 to 10 carbon atoms.

  一个有苯并萘呋喃骨架的有机化合物，用公式（G1）表示。在公式（G1）中，A代表一个芘骨架。在芘骨架有取代基的情况下，取代基是一个二取代或未取代的芳基氨基基团，每个芳基含有6至13个碳原子，一个取代或未取代的含有6至13个碳原子的芳基，一个含有1至7个碳原子的烷基，一个取代或未取代的含有3至20个碳原子的单环饱和碳氢基团，或一个取代或未取代的含有7至10个碳原子的多环饱和碳氢基团。芳基氨基基团的两个芳基可以相同也可以不同。在由公式（G1-1）表示的X1中，R6和R7中的一个与公式（G1）中的N结合，另一个代表一个含有1至7个碳原子的烷基，一个取代或未取代的含有3至20个碳原子的单环饱和碳氢基团，或一个取代或未取代的含有7至10个碳原子的多环饱和碳氢基团。
• REAGENTS AND METHODS FOR REPLICATION, TRANSCRIPTION, AND TRANSLATION IN SEMI-SYNTHETIC ORGANISMS
  申请人：The Scripps Research Institute

  公开号：US20200392550A1

  公开（公告）日：2020-12-17

  Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

  本文揭示了一种用于增加含有一个或多个非天然氨基酸的蛋白质或多肽的生产的组合物、方法、细胞、工程微生物和试剂盒。此外，还提供了一种用于增加编码非天然氨基酸的非天然核酸在工程细胞或半合成生物体中的保留的组合物、细胞、工程微生物和试剂盒。
• A Chiral Iron Disulfonate Catalyst for the Enantioselective Synthesis of 2-Amino-2′-hydroxy-1,1′-binaphthyls (NOBINs)
  作者：Alina Dyadyuk、Vlada Vershinin、Hadas Shalit、Hen Shalev、Nagnath Yadav More、Doron Pappo

  DOI：10.1021/jacs.1c13020

  日期：2022.3.2

  yields and enantioselective ratios (up to 99% yield and 96:4 er). The [Fe((Ra)-BINSate)]+ catalyst was designed as a chiral version of FeCl3 with multicoordination sites available for binding the two coupling partners 1 and 2 as well as the oxidant. Our structure–selectivity and activity study, which covered most of the important positions in the NOBIN scaffold, revealed the effect of different substitution

  报道了一种用于不对称催化的新型手性氧化还原二磺酸铁络合物。[Fe(( R a )-BINSate)] + (BINSate = 1,1'-binaphthalene-2,2'-disulfonate) 配合物有效促进 2-萘酚 ( 1 ) 和 2-氨基萘之间的对映选择性氧化交叉偶联衍生物 ( 2 )，提供光学富集的 ( R a )-2-amino-2'-hydroxy-1,1'-binaphthyls (NOBINs)，具有出色的产率和对映选择性比（高达 99% 的产率和 96:4 er）。[Fe(( Ra ) -BINSate )] +催化剂被设计为 FeCl 3的手性形式具有可用于结合两个偶联配偶体1和2以及氧化剂的多配位点。我们的结构选择性和活性研究涵盖了 NOBIN 支架中的大部分重要位置，揭示了不同取代模式对偶联效率和立体选择性的影响。