(3b)-3-[2-(二乙基氨基)乙氧基]-雄甾-5-烯-17-酮盐酸盐(1:1) | 3039-71-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: (3b)-3-[2-(二乙基氨基)乙氧基]-雄甾-5-烯-17-酮盐酸盐(1:1)
• 英文名称: 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
• 英文别名: (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one;hydrochloride
• CAS: 3039-71-2
• 化学式: C25H42ClNO2
• 分子量: 424.1
• InChiKey: GZFYZYBWLCYBMI-MYZJJQSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.67
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• FMO3 inhibitors for treating pain
  申请人：Akron Molecules GmbH

  公开号：EP2674161A1

  公开（公告）日：2013-12-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.

  本发明涉及治疗疼痛和相关疾病的新疗法，以及用于上述疗法的药物化合物。
• COMPOUNDS AND METHODS FOR TREATING PAIN
  申请人：Akron Molecules GmbH

  公开号：EP2637649A2

  公开（公告）日：2013-09-18
• Methods for preventing acute clinical vascular events in a subject
  申请人：The Trustees of Columbia University

  公开号：US20040259853A1

  公开（公告）日：2004-12-23

  This invention provides methods for: (i) inhibiting macrophage death, (ii) inhibiting atherosclerotic lesional complications, and (iii) inhibiting necrosis, plaque rupture and/or superficial erosion, in a subject having, or at increased risk for developing, cardiovascular disease which comprise administering to the subject an effective amount of an amphiphilic compound or a pharmaceutically acceptable salt thereof which (i) inhibits the intracellular transport of cholesterol within cells or (ii) inhibits free cholesterol-induced death of cells, wherein the transport is from an intracellular cholesterol storage site to the endoplasmic reticulum. This invention also provides articles of manufacture comprising an amphiphilic compound which inhibits the intracellular transport of cholesterol from an intracellular cholesterol storage site to the endoplasmic reticulum in cells, for use in inhibiting (i) macrophage death, (ii) atherosclerotic lesional complications, or (iii) necrosis, plaque rupture and/or superficial erosion, in a subject having, or at increased risk for developing, cardiovascular disease.
• Compounds and Methods for Treating Pain
  申请人：Penninger Josef

  公开号：US20130252924A1

  公开（公告）日：2013-09-26

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
• [EN] COMPOUNDS AND METHODS FOR TREATING PAIN<br/>[FR] COMPOSÉS ET PROCÉDÉS DE TRAITEMENT DE LA DOULEUR
  申请人：AKRON MOLECULES GMBH

  公开号：WO2012062925A2

  公开（公告）日：2012-05-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.