The 13C chemical shifts of 30 substituted 5β,14β-hydroxysteroids are described and discussed. Substituent chemical shifts for 12α- and 12β-hydroxy groups were evaluated, and interesting γ effects were observed. A correlation is shown to exist between the 1H shifts of H-17 and the 13C shifts of C-17 for various C-12 substituents. A relationship for the distance of the substituent at C-12 from H-17 in the 14β,20-lactones was demonstrated, where an increased distance between these atoms is associated with smaller shift differences.
描述并讨论了 30 种取代的 5β,14β-羟基类
固醇的 13C
化学位移。评估了 12α-和 12β-羟基的取代基
化学位移,并观察到有趣的 γ 效应。对于各种 C-12 取代基,H-17 的 1H 位移和 C-17 的 13C 位移之间存在相关性。证明了 14β,20-内酯中 C-12 处取代基距 H-17 的距离的关系,其中这些原子之间的距离增加与较小的位移差异相关。