(4-氯丁基)二苯胺 | 101436-39-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (4-氯丁基)二苯胺
• 英文名称: (4-chlorobutyl)diphenylamine
• 英文别名: (4-Chlor-butyl)-diphenyl-amin；N-(4-chlorobutyl)-N-phenylaniline
• CAS: 101436-39-9
• 化学式: C₁₆H₁₈ClN
• 分子量: 259.779
• InChiKey: KXMVKKUOAGNPLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-氯丁基)二苯胺 、 二乙胺 生成 N,N-diethyl-N',N'-diphenylbutane-1,4-diamine
  参考文献：
  名称：

  Nutrition in Cancer Prevention: An Integrated Approach

  摘要：

  There is considerable evidence that the war on cancer is not being won. There is, however, strong evidence that a substantial fraction of cancer can be prevented by using existing nutritional knowledge. In this paper we discuss strategies for reducing cancer incidence by implementing this knowledge. The most obvious route for persuading large numbers to change their diets is by individual counseling in a health-care setting, public education campaigns and interventions at the worksite. However, such health promotion actions have met with only limited success. For efforts to change population diets to be successful, a vital component must include changes in government policies. Examples of the tools that need to be employed are restrictions on advertising and marketing. Effective action will likely require an economic dimension, namely the employment of taxation and subsidies, for instance, by taxing unhealthy food choices and by subsidizing fruit and vegetables.

  DOI：

  10.1080/07315724.2002.10719197
• 作为产物：
  描述：

  (4-phenoxy-butyl)-diphenyl-amine 在 盐酸 、 水 作用下， 生成 (4-氯丁基)二苯胺
  参考文献：
  名称：

  Nutrition in Cancer Prevention: An Integrated Approach

  摘要：

  There is considerable evidence that the war on cancer is not being won. There is, however, strong evidence that a substantial fraction of cancer can be prevented by using existing nutritional knowledge. In this paper we discuss strategies for reducing cancer incidence by implementing this knowledge. The most obvious route for persuading large numbers to change their diets is by individual counseling in a health-care setting, public education campaigns and interventions at the worksite. However, such health promotion actions have met with only limited success. For efforts to change population diets to be successful, a vital component must include changes in government policies. Examples of the tools that need to be employed are restrictions on advertising and marketing. Effective action will likely require an economic dimension, namely the employment of taxation and subsidies, for instance, by taxing unhealthy food choices and by subsidizing fruit and vegetables.

  DOI：

  10.1080/07315724.2002.10719197

文献信息

• Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof
  申请人：——

  公开号：US20030032801A1

  公开（公告）日：2003-02-13

  A compound having the structural formula 1 or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4, 5 or 6; Y is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or 2 wherein R 1 and R 2 are each independently, H, a heteroatom, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and wherein each ring structure are independently substituted or unsubstituted is disclosed. Also disclosed are chemosensitizing agents and methods of modulating, attenuating, reversing, or affecting a cell's or organism's resistance to a given drug such as an antimalarial.

  一种具有结构式1的化合物，或其药物可接受的盐或前药，其中X是取代或未取代的烷基或杂原子; n为4、5或6; Y是取代或未取代的烷基、环烷基、杂环烷基、芳基、杂芳基或2，其中R1和R2各自独立地为H、杂原子、取代或未取代的烷基、环烷基、杂环烷基、芳基或杂芳基;并且每个环结构都是独立取代或未取代的。还公开了化学增敏剂和调节、减弱、逆转或影响细胞或生物对给定药物（如抗疟药）的耐药性的方法。
• Electroless copper plating of ferrous metal substrates
  申请人：——

  公开号：US20040052961A1

  公开（公告）日：2004-03-18

  The present invention provides a continuous wire drawings process, wherein ferrous metal is drawn through multiple dies, in which the wire is coated in-line in an electroless coppering step between two wire drawing stages by being passed through a bath using transport means comprising ferrous metal components which contact solution in the bath, the bath containing an aqueous solution containing copper ions, bromide ions, a water soluble lubricant and an inhibitor compound such that a coating of copper is deposited on to the ferrous metal surface. A treatment composition as well as dry and liquid concentrate compositions are also described.

  本发明提供了一种连续拉丝工艺，在该工艺中，黑色金属通过多个模具拉丝，在两个拉丝阶段之间的无电解镀铜步骤中，线材被在线镀上一层铜，镀铜过程中，线材通过一个熔池，熔池中含有与熔池中溶液接触的黑色金属成分的传输装置，熔池中含有含铜离子、溴离子、水溶性润滑剂和抑制剂化合物的水溶液，从而在黑色金属表面沉积一层铜。此外，还介绍了一种处理组合物以及干浓缩物和液浓缩物组合物。
• US6800618B2
  申请人：——

  公开号：US6800618B2

  公开（公告）日：2004-10-05
• [EN] CHEMOSENSITIZING AGENTS AGAINST CHLOROQUINE RESISTANT PLASMODIUM FALCIPARUM AND METHODS OF MAKING AND USING THEREOF<br/>[FR] AGENTS DE CHIMIOSENSIBILISATION CONTRE PLASMODIUM FALCIPARUM RESISTANT A LA CHLOROQUINE ET LEURS PROCEDES D'UTILISATION
  申请人：US ARMY MEDICAL RES AND MATERI

  公开号：WO2002089810A1

  公开（公告）日：2002-11-14

  A compound having the structural formula or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4,5 or 6; Y is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or wherein R1 and R2 are each independently, H, a heteroatom, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and wherein each ring structure are independently substituted or unsubstituted is disclosed. Also disclosed are chemosensitizing agents and methods of modulating, attenuating, reversing, or affecting a cell's or organism's resistance to a given drug such as an antimalarial.
• Nutrition in Cancer Prevention: An Integrated Approach
  作者：Norman J. Temple、Audrey L. Balay-Karperien

  DOI：10.1080/07315724.2002.10719197

  日期：2002.4

  There is considerable evidence that the war on cancer is not being won. There is, however, strong evidence that a substantial fraction of cancer can be prevented by using existing nutritional knowledge. In this paper we discuss strategies for reducing cancer incidence by implementing this knowledge. The most obvious route for persuading large numbers to change their diets is by individual counseling in a health-care setting, public education campaigns and interventions at the worksite. However, such health promotion actions have met with only limited success. For efforts to change population diets to be successful, a vital component must include changes in government policies. Examples of the tools that need to be employed are restrictions on advertising and marketing. Effective action will likely require an economic dimension, namely the employment of taxation and subsidies, for instance, by taxing unhealthy food choices and by subsidizing fruit and vegetables.