(6-溴-己基)-二乙胺 | 74509-66-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (6-溴-己基)-二乙胺
• 英文名称: (6-bromo-hexyl)-diethyl-amine
• 英文别名: 6-(diethylamino)hexyl bromide；diethyl-(6-bromo-hexyl)-amine；6-Brom-1-diaethylamino-hexan；Diaethyl-(6-brom-hexyl)-amin；6-Bromo-N,N-diethylhexan-1-amine
• CAS: 74509-66-3
• 化学式: C₁₀H₂₂BrN
• 分子量: 236.195
• InChiKey: GGSFATGQTSRBQK-UHFFFAOYSA-N

物化性质

• 沸点：
  253.7±23.0 °C(Predicted)
• 密度：
  1.103±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921199090

反应信息

• 作为反应物：
  描述：

  (6-溴-己基)-二乙胺 生成 (6-diethylamino-hexyl)-phosphonic acid ; hydrochloride
  参考文献：
  名称：

  HETEROCYCLIC PHOSPHONIC ACIDS. II

  摘要：

  DOI：

  10.1021/jo01127a015
• 作为产物：
  描述：

  1-溴-6-甲氧基己烷 在 氢溴酸 作用下， 生成 (6-溴-己基)-二乙胺
  参考文献：
  名称：

  Drake et al., Journal of the American Chemical Society, 1946, vol. 68, p. 1542

  摘要：

  DOI：

文献信息

• Predictors and Incidence of Urinary Incontinence in Elderly Canadians With and Without Dementia — A Five-Year Follow Up: The Canadian Study of Health and Aging
  作者：Truls Østbye、Steinar Hunskaar、Elizabeth Sykes

  DOI：10.1017/s0714980800000672

  日期：——

  Based on the national Canadian Study of Health and Aging, the objective of this study was to determine the importance of socio-demographic and medical factors, cognitive and functional status as predictors of the development of urinary incontinence, and to estimate five-year incidence by sex and age group. Participants from the Canadian Study of Health and Aging who underwent a clinical examination in 1992 and were continent for urine at the time were followed up and their continence status was again determined in 1997. Multivariate logistic regression models with daily incontinence and daily or less than daily incontinence as the outcomes were developed separately for male (n = 306) and female (n = 520) survivors. Predictor variables were introduced in the following chunks: socio-demographic factors; cognitive status; functional status, diabetes and stroke. Five-year cumulative incidence of daily and less than daily incontinence by sex and age group was also estimated. Results indicated that the incidence of urinary incontinence was higher in women than in men, and increased by age in both men and women. Especially among men, those in institutions were much more likely to develop urinary incontinence than those in the community. Incontinence increased dramatically with severity of dementia, less so with physical immobility. Diabetes mellitus was related to the development incontinence in men but not in women, prior stroke was related to development of incontinence in both sexes. It is concluded that urinary incontinence is common in older persons, and enquiries about its presence should be part of routine medical and nursing assessment of older persons. Those who develop incontinence commonly have dementia and are physically impaired. The extent of assessment and management should be carefully tailored to each individual patient.

  摘要本研究以加拿大全国健康与老龄化研究为基础，旨在确定社会人口和医疗因素、认知和功能状况对尿失禁发生的重要预测作用，并按性别和年龄组估计五年的发病率。对加拿大健康与老龄化研究（Canadian Study of Health and Aging）中于 1992 年接受临床检查并在当时排尿的参与者进行了跟踪调查，并于 1997 年再次确定了他们的尿失禁状况。分别为男性（306 人）和女性（520 人）幸存者建立了以每日尿失禁和每日或少于每日尿失禁为结果的多变量逻辑回归模型。预测变量分为以下几组：社会人口因素、认知状况、功能状况、糖尿病和中风。此外，还估算了按性别和年龄组分列的每日尿失禁和小于每日尿失禁的五年累计发生率。结果表明，女性尿失禁的发生率高于男性，而且随着年龄的增长，男女尿失禁的发生率均有所上升。尤其是在男性中，住在养老院的人比住在社区的人更容易出现尿失禁。尿失禁随痴呆症的严重程度而急剧增加，但随身体活动不便而增加。糖尿病与男性尿失禁的发生有关，但与女性无关。结论是，尿失禁在老年人中很常见，对老年人进行常规医疗和护理评估时应询问是否存在尿失禁。出现尿失禁的老年人通常患有痴呆症且身体机能受损。评估和处理的程度应根据每位患者的具体情况认真制定。
• Neuromuscular Blocking Agents
  作者：D Edwards、J J Lewis、J B Stenlake、M S Zoha

  DOI：10.1111/j.2042-7158.1958.tb10389.x

  日期：2011.4.12

  The preparation of two further NSN-tris-ethonium compounds, 9-ethyl-9-thioniaheptadecylenebis(triethylammonium) triiodide (dioctasulphonium triethiodide; DOSE) and 11-ethyl-11-thioniaheneicosylenebis(triethylammonium) triiodide (didecasulphonium triethiodide; DDSE) is described. The bis-quaternary compound 7-dioxothiatridecylenebis(triethylammonium iodide), and the NNN-tris-quaternary compounds 7:7-diethyl-7-azoniatridecylenebis (triethylammonium) triiodide (dihexazonium triethiodide; DHAE), 9:9-diethyl-9-azoniaheptadecylenebis(triethylammonium triiodide (dioctazonium triethiodide; DOAE) and 11:11-diethyl-11-azoniahenicosylenebis(triethylammonium) triiodide (didecazonium triethiodide; DDAE) have also been synthesised. All the compounds possess neuromuscular blocking activity in the gastrocnemius muscle-sciatic nerve preparation of the cat, the phrenic nerve-diaphragm preparation of the rat and kitten and as measured by the rabbit head drop and mouse paralysis methods. Dihexazonium triethiodide and the sulphone 7-dioxathiatridecylenebis(triethylammonium iodide) (dihexone) show tubocurarine-like activity; dioctasulphonium triethiodide and dioctazonium triethiodide were predominantly tubocurarine-like but had some transitional properties, whilst didecasulphonium triethiodide and didecazonium triethiodide resembled decamethonium. Dihexazonium triethiodide was about equipotent with tubocurarine on the cat. Marked species variations in potency were observed. Theoretical implications are discussed.

  摘要：本文描述了两种新的NSN-三乙醇铵化合物的制备方法，分别为9-乙基-9-硫氮庚二烯双(三乙醇铵)三碘化物（二辛磺酸三乙硫碘酸盐；DOSE）和11-乙基-11-硫氮十二烯双(三乙醇铵)三碘化物（二十二磺酸三乙硫碘酸盐；DDSE）。还合成了双季铵化合物7-二氧代硫氮十三烯双(三乙醇铵碘化物)，以及NNN-三季铵化合物7:7-二乙基-7-氮杂硫氮十三烯双(三乙醇铵)三碘化物（二己杂铵三乙硫碘酸盐；DHAE）、9:9-二乙基-9-氮杂硫氮庚二烯双(三乙醇铵)三碘化物（二辛杂铵三乙硫碘酸盐；DOAE）和11:11-二乙基-11-氮杂硫氮十二烯双(三乙醇铵)三碘化物（二十二杂铵三乙硫碘酸盐；DDAE）。所有化合物在猫的腓肠肌-坐骨神经制备、大鼠和小猫的膈神经-膈肌制备，以及通过兔头下降和小鼠麻痹方法测量时均具有神经肌肉阻滞活性。二己杂铵三乙硫碘酸盐和7-二氧代硫氮十三烯双(三乙醇铵碘化物)（二己酮）表现出肌松药物样的活性；二辛磺酸三乙硫碘酸盐和二辛杂铵三乙硫碘酸盐主要表现出肌松药物样的特性，但也具有一些过渡性质，而二十二磺酸三乙硫碘酸盐和二十二杂铵三乙硫碘酸盐类似于十甲铵。在猫中，二己杂铵三乙硫碘酸盐的效力与肉豆蔻碱大致相同。观察到显著的物种差异。讨论了理论意义。
• Breslow et al., Journal of the American Chemical Society, 1946, vol. 68, p. 102
  作者：Breslow et al.

  DOI：——

  日期：——
• Studies in the Quinoline Series. III. The Preparation of Some 8-(ι-Alkylaminoalkylamino)-quinolines¹
  作者：Kenneth N. Campbell、Armiger H. Sommers、James Kerwin、Barbara K. Campbell

  DOI：10.1021/ja01212a051

  日期：1946.8
• Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents
  作者：Maurice P. LaMontagne、Dinesh Dagli、M. Sami Khan、Peter Blumbergs

  DOI：10.1021/jm00183a004

  日期：1980.9

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.