(7Z,10Z,13Z,16Z)-N-(2-羟基乙基)-7,10,13,16-二十二碳四烯酰胺 | 150314-35-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (7Z,10Z,13Z,16Z)-N-(2-羟基乙基)-7,10,13,16-二十二碳四烯酰胺
• 英文名称: docosatetraenoyl ethanolamide
• 英文别名: N-(2-hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide；DEA；Adrenoyl-ethanolamine；(7Z,10Z,13Z,16Z)-N-(2-hydroxyethyl)docosa-7,10,13,16-tetraenamide
• CAS: 150314-35-5
• 化学式: C₂₄H₄₁NO₂
• 分子量: 375.595
• InChiKey: FMVHVRYFQIXOAF-DOFZRALJSA-N

物化性质

• 沸点：
  544.5±50.0 °C(Predicted)
• 密度：
  0.932±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：10mg/mL； DMSO：30mg/mL；乙醇：100mg/mL；乙醇:PBS (1:2): 8 mg/ml; PBS（pH 7.2）：<100 μg/ml
• 物理描述：
  Solid
• 碰撞截面：
  202.37 Ų [M+H]+ [CCS Type: TIMS, Method: single field calibrated]
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  廿二碳四烯酸 在 草酰氯 作用下， 生成 (7Z,10Z,13Z,16Z)-N-(2-羟基乙基)-7,10,13,16-二十二碳四烯酰胺
  参考文献：
  名称：

  大脑中与大麻素受体结合的两种新的不饱和脂肪酸乙醇酰胺。

  摘要：

  DOI：

  10.1021/jm00072a026

文献信息

• REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Ramot at Tel Aviv University, Ltd.

  公开号：EP2704793B1

  公开（公告）日：2019-07-17
• USE OF CANNABINOID COMPOUNDS FOR STIMULATING MELANOGENESIS
  申请人：Zuccolo Michela

  公开号：US20140193349A1

  公开（公告）日：2014-07-10

  The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R 1 represents a hydrogen atom or a C 1 -C 30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R 2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C 1 -C 6 alkyl groups; R 3 and R 4 form, together with the carbon atom which bears them, an oxo group or else R 3 and R 4 represent a hydrogen atom; R 5 represents a hydrogen atom or a C 1 -C 6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R 6 )—, with R 6 representing a hydrogen atom or a C 1 -C 6 alkyl group; represents a single or double bond; n is 1, 2 or 3, preferentially 1 or 2; it being understood that, when R 3 and R 4 together form an oxo group with the carbon atom which bears them and X represents an oxygen atom, then R 1 cannot represent a hydroxymethyl group, as an agent for coloring keratin materials. It also relates to one of these specific cannabinoid compounds for use thereof in the treatment of vitiligo or pityriasis versicolor, to nontherapeutic cosmetic processes for coloring the skin or for treating canities, comprising the topical application to the skin and/or head hair, or the oral administration, of a composition comprising, in a physiologically acceptable medium, one of these cannabinoid compounds, and to a process for selecting an active agent which promotes the pigmentation of keratin materials.
• US8420602B2
  申请人：——

  公开号：US8420602B2

  公开（公告）日：2013-04-16
• US9192670B2
  申请人：——

  公开号：US9192670B2

  公开（公告）日：2015-11-24
• US9326927B2
  申请人：——

  公开号：US9326927B2

  公开（公告）日：2016-05-03