(8CI)-6-氟喹唑啉 | 16499-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: (8CI)-6-氟喹唑啉
• 英文名称: 6-Fluor-chinazolin
• 英文别名: 6-Fluoroquinazoline
• CAS: 16499-44-8
• 化学式: C₈H₅FN₂
• mdl: MFCD18448850
• 分子量: 148.14
• InChiKey: JFMDVMJEMZLFKV-UHFFFAOYSA-N

物化性质

• 沸点：
  246.1±13.0 °C(Predicted)
• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

文献信息

• NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN
  申请人：FORMA THERAPEUTICS, INC.

  公开号：US20160002188A1

  公开（公告）日：2016-01-07

  The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

  本发明涉及用于抑制FASN的化合物和组合物，它们的合成，应用和解毒剂。本发明的一个示例化合物如下所示：
• Compounds and compositions for inhibition of FASN
  申请人：FORMA Therapeutics, Inc.

  公开号：US10399951B2

  公开（公告）日：2019-09-03

  The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.

  本发明涉及抑制 FASN 的化合物和组合物、其合成、应用和解毒剂。
• METHODS OF USING FASN INHIBITORS
  申请人：FORMA Therapeutics, Inc.

  公开号：US20170312273A1

  公开（公告）日：2017-11-02

  The present disclosure relates to methods of treating, preventing or ameliorating a TH17- or CSF1-mediated disease or disorder such as cancer, immunological disorders, and obesity by administering to a patient in need thereof a therapeutically effective amount of a FASN inhibitor, or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof.
• TREATMENT OF GLIOBLASTOMA WITH FASN INHIBITORS
  申请人：FORMA Therapeutics, Inc.

  公开号：US20210252011A1

  公开（公告）日：2021-08-19

  The present disclosure relates to methods of treating glioblastoma by administering to a patient in need thereof a FASN inhibitor.