N-(1-azabicyclo[2.2.2]oct-3-yl)-7-hydroxythieno[3.2-b]pyridine-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: N-(1-azabicyclo[2.2.2]oct-3-yl)-7-hydroxythieno[3.2-b]pyridine-6-carboxamide
• 英文别名: N-(1-azabicyclo[2.2.2]octan-3-yl)-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide
• 化学式: C₁₅H₁₇N₃O₂S
• 分子量: 303.385
• InChiKey: AFUWQWYPPZFWCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Antiviral agents
  申请人：——

  公开号：US20040138449A1

  公开（公告）日：2004-07-15

  The invention provides a compound of formula I: 1 wherein G, R 2 , and R 3 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.

  本发明提供了一种公式I的化合物： 1 其中G，R 2 ，和R 3 具有规范中定义的任何值，或其药用可接受盐，以及用于制备该化合物或盐的有用过程和中间体，以及使用该化合物或盐治疗疱疹病毒感染的方法。
• ANTIVIRAL COMPOUNDS
  申请人：——

  公开号：US20040242884A1

  公开（公告）日：2004-12-02

  The invention provides a compound of formula I: 1 wherein G, R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpes virus infection using such compounds or salts.

  本发明提供了一种I式化合物：1，其中G，R2，R3和R4具有规范中定义的任何值，或其药学上可接受的盐，以及用于制备这种化合物或盐的有用中间体和过程，以及使用这种化合物或盐预防或治疗疱疹病毒感染的方法。
• PREVENTIVE OR THERAPEUTIC AGENTS FOR GASTRIC OR ESOPHAGEAL REGURGITATION
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1256581A1

  公开（公告）日：2002-11-13

  The compound of the following formula: wherein R1 and R2 independently represent a hydrogen atom or a lower alkyl group; A represents a group selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group, 1-azabicyclo[2.2.2]octyl group, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof or a hydrate thereof has both improving effect on enterokinetic functions and suppressing effect on acid secretion, and also is highly safe. Accordingly, the substance is useful as preventive or therapeutic medicament for a gastroesophageal reflux disease.

  下式的化合物： 其中 R1 和 R2 分别代表氢原子或低级烷基；A 代表选自 1-氮杂双环[3.2.2]壬基、1-氮杂双环[2.2.2]辛基或其 N-氧化物组成的组，或其药学上可接受的盐或其水合物，具有改善肠动力功能和抑制胃酸分泌的作用，而且安全性高。因此，该物质可用作胃食管反流病的预防或治疗药物。
• Preventive or therapeutic agents for gastric or esophageal regurgitation
  申请人：——

  公开号：US20030130304A1

  公开（公告）日：2003-07-10

  The compound of the following formula: 1 wherein R 1 and R 2 independently represent a hydrogen atom or a lower alkyl group; A represents a group selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group, 1-azabicyclo[2.2.2]octyl group, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof or a hydrate thereof has both improving effect on enterokinetic functions and suppressing effect on acid secretion, and also is highly safe. Accordingly, the substance is useful as preventive or therapeutic medicament for a gastroesophageal reflux disease.

  下式化合物 1 其中 R 1 和 R 2 A 代表选自 1-氮杂双环[3.2.2]壬基、1-氮杂双环[2.2.2]辛基、或其 N-氧化物、或其药学上可接受的盐或其水合物组成的组。因此，该物质可用作胃食管反流病的预防或治疗药物。
• Preventive agent/remedial agent for constipation predominant ibs
  申请人：——

  公开号：US20040248927A1

  公开（公告）日：2004-12-09

  A novel preventive and/or therapeutic medicament for a constipation predominant IBS which contains as the active ingredient a thieno[3,2-b]pyridinecarboxamide derivative represented by the formula (I): 1 wherein R 1 and R 2 each independently represents hydrogen atom or a lower alkyl group and A represents a substituent selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group 1-azabicyclo[2.2.2]octyl group, and the N.oxides thereof, a pharmaceutically acceptable salt thereof, or a solvate or hydrate thereof

  一种新型的预防和/或治疗以便秘为主的肠易激综合征的药物，其活性成分是由式 (I) 所代表的噻吩[3,2-b]吡啶甲酰胺衍生物： 1 其中 R 1 和 R 2 各自独立地代表氢原子或低级烷基，且 A 代表选自以下组别的取代基：1-氮杂双环[3.2.2]壬基 1-氮杂双环[2.2.2]辛基，及其 N.氧化物，其药学上可接受的盐，或其溶液或水合物