8-((2-ethyl-6-methylbenzyl)amino)-N,N-bis(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 8-((2-ethyl-6-methylbenzyl)amino)-N,N-bis(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
• 英文别名: 8-[(2-ethyl-6-methylphenyl)methylamino]-N,N-bis(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
• 化学式: C₂₄H₃₂N₄O₃
• 分子量: 424.5
• InChiKey: FTXBKPOSKGLYOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  90.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] IMIDAZO PYRIDINE DERIVATIVES WHICH INHIBIT GASTRIC ACID SECRETION<br/>[FR] DERIVES D'IMIDAZO PYRIDINE QUI INHIBENT LA SECRETION D'ACIDE GASTRIQUE
  申请人：ASTRA AB

  公开号：WO1999055706A1

  公开（公告）日：1999-11-04

  The present invention relates to imidazo pyridine derivatives of formula (I), in which the phenyl moiety is substituted, and in which the imidazo pyridine moiety is substituted with a carboxyamide group in 6-position, which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.

  本发明涉及公式(I)的咪唑吡啶衍生物，其中苯基基团被取代，咪唑吡啶基团在6位被羧酰胺基团取代，能够抑制外源性或内源性刺激胃酸分泌，因此可用于预防和治疗胃肠道炎症性疾病。
• Novel modified release formulation
  申请人：——

  公开号：US20040067252A1

  公开（公告）日：2004-04-08

  The present invention is directed to a multiparticulate, modified release solid dispersion formulation, comprising a drug substance having a pH-dependent solubility, said drug substance being a compound of the formula I, or a pharmaceutically acceptable salt thereof; a hydrophobic matrix former which is a water-insoluble, non-swelling amphiphilic lipid; and a hydrophilic matrix former which is a meltable, water-soluble excipient; wherein the weight ratio hydrophobic matrix former/hydrophilic matrix former is ≧1; and the particle size is less than 300 &mgr;m. Also a unit dosage of the same, as well as a process for the preparation thereof and the use of the formulation and unit dosage is claimed.

  本发明涉及一种多颗粒、改进释放型固体分散制剂，包括一种溶解度取决于 pH 值的药物，所述药物为式 I 的化合物或其药学上可接受的盐； 疏水基质前体，它是一种不溶于水、无溶胀性的两性脂质；以及亲水基质前体，它是一种可熔化的水溶性赋形剂；其中疏水基质前体/亲水基质前体的重量比为≧1;，粒度小于300&mgr;m。 此外，还要求得到一种相同的单位剂量及其制备工艺，以及该制剂和单位剂量的使用方法。
• IMIDAZO PYRIDINE DERIVATIVES WHICH INHIBIT GASTRIC ACID SECRETION
  申请人：AstraZeneca AB

  公开号：EP1073657A1

  公开（公告）日：2001-02-07
• NOVEL MODIFIED RELEASE FORMULATION
  申请人：AstraZeneca AB

  公开号：EP1361868A1

  公开（公告）日：2003-11-19
• PHARMACEUTICAL COMBINATIONS OF A PROTON PUMP INHIBITOR AND A COMPOUND WHICH MODIFIES GASTROINTESTINAL MOTILITY
  申请人：ALTANA Pharma AG

  公开号：EP1644043A1

  公开（公告）日：2006-04-12