[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 2-oxopropanoate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 2-oxopropanoate
• 化学式: C₁₂H₁₄N₂O₈
• 分子量: 314.25
• InChiKey: PPCWNHMLTUFJBK-PEBGCTIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF MITOCHONDRIAL DISEASES
  申请人：——

  公开号：US20010005719A1

  公开（公告）日：2001-06-28

  Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

  提供了用于治疗与线粒体功能障碍相关的疾病的化合物、组合物和方法。该方法包括向哺乳动物注射含有嘧啶核苷酸前体的组合物，其量足以治疗因线粒体呼吸链缺陷而导致的症状。
• Compositions and methods for treatment of mitochondrial diseases
  申请人：Pro-Neuron, Inc.

  公开号：US20010016576A1

  公开（公告）日：2001-08-23

  Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

  本发明提供了用于治疗与线粒体功能障碍相关的疾病的化合物、组合物和方法。该方法包括向哺乳动物注射含有嘧啶核苷酸前体的组合物，其用量足以治疗由于线粒体呼吸链缺陷引起的症状。
• Compositions and the use thereof the treatment of mitochondrial diseases
  申请人：32 Mott Street Acquisitions I, LLC d/b/a Wellstat Vaccines

  公开号：EP2295063A2

  公开（公告）日：2011-03-16

  There is provided a method for treating or preventing pathophysiological consequences of mitochondrial respiratory chain dysfunction in a mammal comprising administering to said mammal in need of such treatment or prevention an effective amount of a pyrimidine nucleotide. There is also provided a method for reducing side effects of cytotoxic cancer chemotherapy agents by administering a pyrimidine nucleotide precursor, where said cytotoxic chemotherapy agent is not a pyrimidine nucleoside analog.

  提供了一种治疗或预防哺乳动物线粒体呼吸链功能障碍的病理生理后果的方法，该方法包括向需要这种治疗或预防的哺乳动物施用有效量的嘧啶核苷酸。还提供了一种通过施用嘧啶核苷酸前体减少细胞毒性癌症化疗剂副作用的方法，其中所述细胞毒性化疗剂不是嘧啶核苷类似物。
• EP1109453A4
  申请人：——

  公开号：EP1109453A4

  公开（公告）日：2006-11-02
• Compositions and the use thereof in the treatment of mitochondrial diseases
  申请人：Wellstat Therapeutics Corporation

  公开号：EP2295063B1

  公开（公告）日：2017-04-26