2-cyclohexyl-2-(1H-tetrazol-5-yl)-ethylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-cyclohexyl-2-(1H-tetrazol-5-yl)-ethylamine
• 英文别名: 2-cyclohexyl-2-(2H-tetrazol-5-yl)ethanamine
• 化学式: C₉H₁₇N₅
• 分子量: 195.267
• InChiKey: LWKWVEBYSVTKEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  80.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  cyclohexylidene-(2-trityl-2H-tetrazol-5-yl)-acetonitrile 在 platinum(IV) oxide 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 生成 2-cyclohexyl-2-(1H-tetrazol-5-yl)-ethylamine
  参考文献：
  名称：

  Carboxylate bioisosteres of pregabalin

  摘要：

  Several beta-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the alpha(2)-delta Protein examined. Two select compounds with potent affinity for alpha(2)-delta, 8a and 16a, were subsequently tested in vivo in an audiogenic seizure model and found to elicit protective effects. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.083

文献信息

• [EN] TETRAZOLE AND OXADIAZOLONE SUBSTITUTED beta-AMINO ACID DERIVATIVES<br/>[FR] DERIVES DE beta-AMINOACIDES SUBSTITUES PAR TETRAZOLE ET OXADIAZOLONE
  申请人：WARNER LAMBERT CO

  公开号：WO2004078734A1

  公开（公告）日：2004-09-16

  This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula (I, II), wherein G is (III, IV) wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl β-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (α2δ ligands). Such compounds have affinity for the α2δ subunit of a calcium channel.

  这项发明涉及公式(I, II)的新型四唑和氧代噁唑酮β-氨基酸衍生物，其中G为(III, IV)，其中R1至R4如规范中所定义，含有它们的药物组合物以及它们用于治疗各种中枢神经系统和其他疾病的用途。本发明的环丙基β-氨基酸衍生物表现出作为α2δ配体（α2δ配体）的活性。这类化合物对钙通道的α2δ亚基具有亲和力。
• Tetrazole and oxadiazolone substituted beta-amino acid derivatives
  申请人：Barta Sue Nancy

  公开号：US20050014804A1

  公开（公告）日：2005-01-20

  This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula wherein G is wherein R 1 through R 4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl β-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (α2δ ligands). Such compounds have affinity for the α2δ subunit of a calcium channel.

  本发明涉及一种新型四唑和氧二唑酮β-氨基酸衍生物，其化学式为其中G为其中R1到R4如规范中定义，含有它们的药物组合物以及它们用于治疗各种中枢神经系统和其他疾病的用途。本发明的环丙基β-氨基酸衍生物表现出作为α2δ配体（α2δ配体）的活性。这种化合物具有对钙通道的α2δ亚单位的亲和力。
• TETRAZOLE AND OXADIAZOLONE SUBSTITUTED &bgr;-AMINO ACID DERIVATIVES
  申请人：Warner-Lambert Company LLC

  公开号：EP1603890A1

  公开（公告）日：2005-12-14
• COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH 2 LIGANDS AND NSAIDS
  申请人：Recordati Ireland Limited

  公开号：EP2125021B1

  公开（公告）日：2011-06-08
• COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH ALPHA 2DELTA LIGANDS AND NSAIDS
  申请人：Recordati Ireland Limited

  公开号：EP2125021B8

  公开（公告）日：2012-02-15