N-benzyl-2-[(3,4-dichloro-6-oxo-8a-propyl-8,9-dihydro-7H-fluoren-2-yl)oxy]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-benzyl-2-[(3,4-dichloro-6-oxo-8a-propyl-8,9-dihydro-7H-fluoren-2-yl)oxy]acetamide
• 化学式: C₂₅H₂₅Cl₂NO₃
• 分子量: 458.4
• InChiKey: QXFVJHBPESCOFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• US6251898B1
  申请人：——

  公开号：US6251898B1

  公开（公告）日：2001-06-26
• [EN] FLUORENONE COMPOUNDS WITH MODIFIED 7-POSITION SUBSTITUENTS FOR TREATING AND PREVENTING BRAIN AND SPINAL INJURY<br/>[FR] COMPOSES DE FLUORENONE AVEC SUBSTITUANTS DE POSITION 7 MODIFIES DESTINES AU TRAITEMENT ET A LA PREVENTION DE LESIONS MEDULLAIRES ET CEREBRALES
  申请人：QUESTCOR PHARMACEUTICALS INC

  公开号：WO2001014334A1

  公开（公告）日：2001-03-01

  Neuroprotective drugs are disclosed which are analogs of certain previously known fluorenone compounds. The new analogs have structure (I), where X is a lower alkyl, substituted alkyl, or cycloalkyl group, R is selected from certain types of ether, ester, or amide groups, and Y?1 and Y2¿ are halogen, hydrogen, or methyl. These new compounds potently inhibit the unwanted release of excitotoxins by astrocyte cells following an injury or insult to the brain or spinal cord. As an illustration, a number of new analogs were more than 30 times more potent than the previously known lead compound in reducing aspartate release by stressed astrocyte cells. The new analogs can also help reduce swelling in astrocyte cells, and can thereby help promote proper blood flow thrugh the brain following a head injury or other crisis. These new analogs have been shown to work with very good efficacy in in vitro animal models of focal or global brain ischemia. Accordingly, these compounds can reduce brain or spinal cord damage caused by a hypoxic, ischemic, infective, inflammatory, or other injury, crisis, or insult to the brain or spinal cord.