6-Tert-butyl-7-thiophen-2-ylpyrido[2,3-d]pyrimidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 6-Tert-butyl-7-thiophen-2-ylpyrido[2,3-d]pyrimidin-4-amine
• 化学式: C₁₅H₁₆N₄S
• 分子量: 284.4
• InChiKey: GSJMEJPHDCYTSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 6,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSES DE 4-AMINOPYRIDO[2,3-D]PYRIMIDINE A DISUBSTITUTION EN POSITION 6,7
  申请人：ABBOTT LAB

  公开号：WO2001057040A1

  公开（公告）日：2001-08-09

  A compound of formula (I): wherein R?1, R2, R3, R4, and R5¿ are defined, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, and a method of treating cerebral ischemia, epilepsy, nociception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, a process for preparing said compounds, and compounds having the above formula wherein R?1, R2, R3, R4, and R5¿ are separately defined.