4-[[Methyl-(9-propan-2-ylpurin-6-yl)amino]methyl]benzene-1,2-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 4-[[Methyl-(9-propan-2-ylpurin-6-yl)amino]methyl]benzene-1,2-diol
• 化学式: C₁₆H₁₉N₅O₂
• 分子量: 313.35
• InChiKey: KPKJYRUIMVQIPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  87.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Purine derivatives, process for their preparation and use thereof
  申请人：——

  公开号：US20030187261A1

  公开（公告）日：2003-10-02

  The present invention relates to new purine derivatives and their deaza- and aza-analogues, methods for preparing said derivatives, and to their use in suitable utilities, in particular their use in diagnostics and therapeutic methods. The invention relates in particular to purine derivatives with an inhibitory effect on for example cyclin-dependent kinase proteins (sdks), viruses, and proliferation of haemotapoietic and cancer cells.

  本发明涉及新的嘌呤衍生物及其去氮和氮杂类似物，制备这些衍生物的方法，以及它们在适当的实用程序中的使用，特别是它们在诊断和治疗方法中的使用。本发明特别涉及具有抑制作用的嘌呤衍生物，例如对于细胞周期依赖性激酶蛋白（sdks）、病毒和造血和癌细胞增殖等。
• PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF
  申请人：UNIVERSITAIRE INSTELLING ANTWERPEN

  公开号：EP1244668A1

  公开（公告）日：2002-10-02
• [EN] PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF<br/>[FR] DERIVES DE PURINE, PROCEDE DE PREPARATION ET UTILISATION DE CES DERNIERS
  申请人：UNIVERSITAIRE INSTELLING ANTWE

  公开号：WO2001049688A1

  公开（公告）日：2001-07-12

  2-, 6-, 8-, 9-monosubstituted, 2,6-, 2,9-, 6,8-, 6,9-disubstituted and 2,6,8-, 2,6,9-, 6,8,9-trisubstituted purine derivatives and their deaza- and aza- analogues with an inhibitor effect with respect to cyclin-dependent kinase proteins (cdks). Their use as anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds.