1-(1-Benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-(1-Benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
• 英文别名: 1-(1-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-isoquinolin-5-ylurea
• 化学式: C₂₈H₂₇N₃O₂
• 分子量: 437.541
• InChiKey: HLMMYNCSAQLMGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  63.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (isoquinolin-5-yl)carbamic acid phenyl ester 、 cis-1,2,3,4-tetrahydro-6-methoxy-1-(phenylmethyl)-2-naphthalenamine 以 二甲基亚砜 为溶剂， 生成 1-(1-Benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
  参考文献：
  名称：

  Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

  摘要：

  We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.036

文献信息

• Aminotetralin-derived urea modulators of vanilloid VR1 receptor
  申请人：——

  公开号：US20030236280A1

  公开（公告）日：2003-12-25

  This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to &bgr;-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.

  该发明涉及辣椒素受体VR1配体。更具体地，该发明涉及β-氨基四氢萘衍生的脲类化合物，它们是VR1的有效拮抗剂或激动剂，对于治疗和预防哺乳动物的炎症和其他疼痛症状具有用处。
• [EN] AMINOTETRALIN-DERIVED UREA MODULATORS OF VANILLOID VR1 RECEPTOR<br/>[FR] MODULATEURS DE L'UREE DERIVES DE L'AMINOTETRALINE DU RECEPTEUR VANILLOIDE VR1
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2003097586A1

  公开（公告）日：2003-11-27

  This invention is directed to vanilloid receptor VR1 ligands of formula (1). More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.

  本发明涉及式（1）的vanilloid受体VR1配体。更具体地，本发明涉及β-氨基四氢萘衍生的尿素，它们是VR1的有效拮抗剂或激动剂，可用于治疗和预防哺乳动物的炎症和其他疼痛症状。
• AMINOTETRALIN-DERIVED UREA MODULATORS OF VANILLOID VR1 RECEPTOR
  申请人：Codd Ellen

  公开号：US20080097102A1

  公开（公告）日：2008-04-24

  This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.

  本发明涉及辣椒素受体VR1配体。更具体地说，本发明涉及β-氨基四氢萘基脲，它们是VR1的有效拮抗剂或激动剂，用于治疗和预防哺乳动物的炎症和其他疼痛症状。
• US6984647B2
  申请人：——

  公开号：US6984647B2

  公开（公告）日：2006-01-10
• US7678812B2
  申请人：——

  公开号：US7678812B2

  公开（公告）日：2010-03-16