(S)-7-Chloro-5-(cyclopropylmethoxy)-5,10-dihydro-5-(trifluoromethyl)pyrimido[4,5-b]quinoline | 335448-33-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: (S)-7-Chloro-5-(cyclopropylmethoxy)-5,10-dihydro-5-(trifluoromethyl)pyrimido[4,5-b]quinoline
• 英文别名: (5S)-7-chloro-5-(cyclopropylmethoxy)-5-(trifluoromethyl)-10H-pyrimido[4,5-b]quinoline
• CAS: 335448-33-4
• 化学式: C₁₆H₁₃ClF₃N₃O
• 分子量: 355.747
• InChiKey: PIVLQTYRQGRXFL-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Tricyclic compounds useful as HIV reverse transcriptase inhibitors
  申请人：——

  公开号：US20040002498A1

  公开（公告）日：2004-01-01

  The present invention relates to tricyclic compounds of formula (I): 1 or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

  本发明涉及公式（I）的三环化合物：1或其立体异构体形式，立体异构体混合物或其药学上可接受的盐形式，其可用作HIV反转录酶的抑制剂，以及包含其的制药组合物和诊断工具箱，以及使用其治疗病毒感染或作为测定标准或试剂的方法。
• US6593337B1
  申请人：——

  公开号：US6593337B1

  公开（公告）日：2003-07-15
• [EN] PEPTIDES<br/>[FR] PEPTIDES
  申请人：US GOV HEALTH & HUMAN SERV

  公开号：WO2004065411A2

  公开（公告）日：2004-08-05

  Disclosed are compounds which are tripeptides of the formula P-A-B-C or prodrugs thereof, wherein A is an amino acid having a carboxy alkyl group (e.g., carboxy C1-C6 alkyl group), B is tyrosine, phenylalanine, or a substituted tyrosine or phenylalanine, C is a hydrophobic amino acid, and P is an amine protecting group protecting the amine end of A. Also disclosed are pharmaceutical compositions comprising such a compound and a pharmaceutically acceptable carrier, and a method of treating an animal, e.g., a human, exposed to or infected by Yersihia pestis. The compounds find use as anti-bioterrorism agents.