4-amino-2-(ethoxymethyl)-α,α-dimethyl-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinoline-1-ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 4-amino-2-(ethoxymethyl)-α,α-dimethyl-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinoline-1-ethanol
• 英文别名: 4-amino-α,α-dimethyl-2-ethoxymethyl-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-ethanol；1-(4-Amino-2-(ethoxymethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol；1-[4-amino-2-(ethoxymethyl)-6,7,8,9-tetrahydroimidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
• 化学式: C₁₇H₂₆N₄O₂
• 分子量: 318.419
• InChiKey: JGPXFNFCEPOWRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Delivery of immune response modifier compounds using metal-containing particulate support materials
  申请人：3M Innovative Properties Company

  公开号：US20040202720A1

  公开（公告）日：2004-10-14

  The present invention provides immune response modifiers (IRMs) on particulate support materials that includes one or more metals, including alloys or complexes thereof.

  本发明提供了一种包括一种或多种金属（包括合金或配合物）的颗粒支持材料上的免疫应答调节剂（IRM）。
• Delivery of immune response modifier compounds
  申请人：——

  公开号：US20040258698A1

  公开（公告）日：2004-12-23

  The present invention provides immune response modifiers (IRMs) associated with (typically, attached to, and preferably, covalently attached to) macromolecular support materials. The IRM compounds in such IRM-support complexes retain biological activity. Such attachment of an IRM to a macromolecular support material provides for the localized biological activity of the IRM.

  本发明提供了与（通常与、最好是共价连接到）大分子支持材料相关联的免疫应答调节剂（IRM）。这种IRM-支持复合物中的IRM化合物保留生物活性。将IRM连接到大分子支持材料上，实现了IRM的局部生物活性。
• Methods , composition and preparations for delivery of immune response modifiers
  申请人：Zarraga E. Isidro Angelo

  公开号：US20070166384A1

  公开（公告）日：2007-07-19

  A soluble IRM-polymer complex, preparations thereof, and methods of use, wherein the soluble IRM-polymer complex includes one or more IRM compounds attached (e.g., covalently attached) to a polymer (e.g., an alkylene oxide-containing polymer).

  一种可溶性IRM-聚合物复合物，其制备方法以及使用方法，其中可溶性IRM-聚合物复合物包括一个或多个IRM化合物与聚合物（例如，含有烷基氧的聚合物）连接（例如，共价连接）的情况。
• N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide, a pharmaceutical composition comprising the same and use thereof
  申请人：3M Innovative Properties Company

  公开号：EP1719511A2

  公开（公告）日：2006-11-08

  N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide, a pharmaceutical composition comprising the same and use thereof.

  N-[4-(4-氨基-2-乙基-1H-咪唑并[4,5-c]喹啉-1-基)丁基]甲磺酰胺、由其组成的药物组合物及其用途。
• A MIXTURE FOR TRANSDERMAL DELIVERY OF LOW& AND HIGH MOLECULAR WEIGHT COMPOUNDS
  申请人：ORYXE

  公开号：EP3001990A1

  公开（公告）日：2016-04-06

  Aspects of the present invention concern the discovery of a transdermal delivery composition that can deliver low, medium and high molecular weight pharmaceuticals and cosmetic agents. Embodiments include transdermal delivery compositions with therapeutic and cosmetic application, transdermal delivery devices for providing said transdermal delivery compositions to subjects in need thereof, and methods of making and using of the foregoing.

  本发明的各个方面涉及一种透皮给药组合物的发现，该组合物可以给药低、中和高分子量的药物和化妆品制剂。本发明的实施方案包括具有治疗和美容用途的透皮给药组合物、用于向有需要的受试者提供所述透皮给药组合物的透皮给药装置，以及制造和使用上述组合物的方法。