7-Trifluoromethyl-3-(5-trifluoromethylpyridin-2-yl)imidazo[1,2-alpha]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]嘧啶
• 英文名称: 7-Trifluoromethyl-3-(5-trifluoromethylpyridin-2-yl)imidazo[1,2-alpha]pyrimidine
• 英文别名: 7-(trifluoromethyl)-3-[5-(trifluoromethyl)pyridin-2-yl]imidazo[1,2-a]pyrimidine
• 化学式: C₁₃H₆F₆N₄
• 分子量: 332.2
• InChiKey: YKRXONFPFNGAMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-溴-5-(三氟甲基)吡啶 、 3-Tributylstannanyl-7-trifluoromethyl-imidazo[1,2-a]pyrimidine 在 silica gel 、 二氯甲烷 、 甲苯 作用下， 以gave 7-trifluoromethyl-3-(5-trifluoromethylpyridin-2-yl)imidazo[1,2-α]pyrimidine as a yellow solid的产率得到7-Trifluoromethyl-3-(5-trifluoromethylpyridin-2-yl)imidazo[1,2-alpha]pyrimidine
  参考文献：
  名称：

  Imidazo-pyrimidine derivatives as ligands for GABA receptors

  摘要：

  一类在3位取代了一个选择性取代的五元或六元杂环芳香环的咪唑[1,2-α]嘧啶衍生物是GABAA受体的选择性配体，尤其对其中的α2和/或α3和/或α5亚基具有良好的亲和力，因此对于治疗和/或预防中枢神经系统的不良症状，包括焦虑、抽搐和认知障碍具有益处。

  公开号：

  US07030128B2

文献信息

• Imidazo-pyrimidine derivatives as ligands for gaba receptors
  申请人：——

  公开号：US20040092533A1

  公开（公告）日：2004-05-13

  A class of imidazo[1,2-&agr;]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABA A receptors, in particular having good affinity for the &agr;2 and/or &agr;3 and/or &agr;5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

  一类咪唑[1,2-&agr;]嘧啶衍生物，在3位被一个可选择取代的五元或六元杂环芳香环所取代，是GABAA受体的选择性配体，特别是对其&agr;2和/或&agr;3和/或&agr;5亚单位具有良好的亲和力，因此对于治疗和/或预防中枢神经系统的不良病症，包括焦虑、惊厥和认知障碍具有益处。
• IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1383768A1

  公开（公告）日：2004-01-28
• ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST
  申请人：Pfizer Japan, Inc.

  公开号：EP1732893A2

  公开（公告）日：2006-12-20
• [EN] IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-PYRIMIDINE EN TANT QUE LIGANDS POUR RECEPTEURS GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2002076983A1

  公开（公告）日：2002-10-03

  A class of imidazo[1,2-α]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
• [EN] ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST<br/>[FR] COMPOSES ALPHA-ARYLE OU HETEROARYLE METHYLE BETA PIPERIDINO PROPANAMIDE EN TANT QU'ANTAGONISTE DU RECEPTEUR ORL1
  申请人：PFIZER JAPAN INC

  公开号：WO2005092858A2

  公开（公告）日：2005-10-06

  This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a hydrogen atom, or the like; R4 represents a hydrogen atom or the like; (formula II) represents one of the following or the like; R5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxgen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.