7-amino-3-ethyl-1-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 7-amino-3-ethyl-1-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
• 英文别名: 7-Amino-1-(3,5-dimethoxyphenyl)-3-ethylpyrido[2,3-d]pyrimidine-2,4-dione
• 化学式: C₁₇H₁₈N₄O₄
• 分子量: 342.354
• InChiKey: JBBKSBCNBQDFOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  98
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 7-Aminopyrido(2,3-d)-pyrimidine derivatives for treatment of bronchial asthma
  申请人：NIPPON ZOKI PHARMACEUTICAL CO., LTD.

  公开号：EP0994113A2

  公开（公告）日：2000-04-19

  The invention provides 7-amino-1-phenylpyrido[2,3-d]pyrimidine-2,4-dione derivatives of the formula (I) or a pharmaceutically acceptable salt or hydrate thereof; wherein R1 is hydrogen, lower alkenyl, phenyl or optionally substituted lower alkyl which is optionally substituted with a substituent selected from oxo; lower alkoxy; phenyl which is optionally substituted with one or more lower alkyl, lower alkoxy, carboxyl, lower alkoxycarbonyl, mercapto, halogen, trifluoromethyl and/or nitro; naphthyl; furyl; isoxazolyl which is optionally substituted with one or more lower alkyl; pyridyl which is optionally substituted with one or more lower alkyl and/or halogen; thienyl which is optionally substituted with halogen; and 1,3-dioxolanyl; and R2, R3 and R4 each independently is hydrogen, halogen, lower alkoxy, benzyloxy, carboxyl or lower alkoxycarbonyl, which is useful for a therapeutic agent for bronchial asthma by exhibiting excellent bronchial dilating action as well as high safety and a favorable behavior in vivo.

  本发明提供了式 (I) 的 7-氨基-1-苯基吡啶并[2,3-d]嘧啶-2,4-二酮衍生物或其药学上可接受的盐或水合物； 其中 R1 是氢、低级烯基、苯基或任选被选自以下取代基取代的低级烷基：氧代；低级烷氧基；任选被一个或多个低级烷基、低级烷氧基、羧基、低级烷氧羰基、巯基、卤素、三氟甲基和/或硝基取代的苯基；萘基；呋喃基；任选被一个或多个低级烷基取代的异噁唑基；任选被一个或多个低级烷基和/或卤素取代的吡啶基；任选被卤素取代的噻吩基；以及 1,3-二氧戊环基；以及 R2、R3 和 R4 各自独立地为氢、卤素、低级烷氧基、苄氧基、羧基或低级烷氧羰基、 该化合物具有优异的支气管扩张作用，安全性高，在体内表现良好，可作为支气管哮喘的治疗剂。
• US6242452B1
  申请人：——

  公开号：US6242452B1

  公开（公告）日：2001-06-05