N'-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-N,N,2,2-tetramethylpropane-1,3-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N'-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-N,N,2,2-tetramethylpropane-1,3-diamine
• 化学式: C₂₃H₂₈N₆O
• 分子量: 404.5
• InChiKey: XFVLXFAEJBERAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  67.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHOD OF TREATING CANCER
  申请人：Merck & Co., Inc.

  公开号：EP1496981A2

  公开（公告）日：2005-01-19
• [EN] METHOD OF TREATING CANCER<br/>[FR] METHODE DE TRAITEMENT DU CANCER
  申请人：MERCK & CO INC

  公开号：WO2003084473A2

  公开（公告）日：2003-10-16

  The present invention is directed to a method of treating cancer which comprises administration of a compound which selectively inhibits the activity of one or two of the isoforms of Akt, a serine/threonine protein kinase. The invention is particularly directed to the method wherein the compound is dependent on the presence of the pleckstrin homology domain of Akt for its inhibitory activity.