3-Ethyl-6-cyclopentylamino-8-cyclopropyl-3,7-dihydro-2h-purine-2-thione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-Ethyl-6-cyclopentylamino-8-cyclopropyl-3,7-dihydro-2h-purine-2-thione
• 英文别名: 6-(cyclopentylamino)-8-cyclopropyl-3-ethyl-7H-purine-2-thione
• 化学式: C₁₅H₂₁N₅S
• 分子量: 303.4
• InChiKey: CHCBKXPFGFNOJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  88.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 6-Amino purine derivatives having PDE-IV inhibition activity and intermediates
  申请人：Euroceltique S.A.

  公开号：EP0916672A1

  公开（公告）日：1999-05-19

  Novel purine derivatives and their isoguanine and dithioxanthine precursor compounds are disclosed. These compounds have bronchial and tracheal relaxation and/or anti-inflammatory activity. The invention is also related to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In certain preferred embodiments, the invention relates to 3-substituted and 3,8-disubstituted 6-amino purine derivatives.

  本研究公开了新型嘌呤衍生物及其异鸟嘌呤和二硫黄嘌呤前体化合物。这些化合物具有舒张支气管和气管和/或抗炎活性。本发明还涉及它们的制备工艺、含有它们的药物组合物及其医疗用途。在某些优选的实施方案中，本发明涉及 3-取代和 3,8-二取代的 6-氨基嘌呤衍生物。
• 6-Amino purine derivatives having PDE-IV inhibition activity
  申请人：Euroceltique S.A.

  公开号：EP0916673A1

  公开（公告）日：1999-05-19

  Novel purine derivatives and their isoguanine and dithioxanthine precursor compounds are disclosed. These compounds have bronchial and tracheal relaxation and/or anti-inflammatory activity. The invention is also related to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In certain preferred embodiments, the invention relates to 3-substituted and 3,8-disubstituted 6-amino purine derivatives.

  本研究公开了新型嘌呤衍生物及其异鸟嘌呤和二硫黄嘌呤前体化合物。这些化合物具有舒张支气管和气管和/或抗炎活性。本发明还涉及它们的制备工艺、含有它们的药物组合物及其医疗用途。在某些优选的实施方案中，本发明涉及 3-取代和 3,8-二取代的 6-氨基嘌呤衍生物。
• US5939422A
  申请人：——

  公开号：US5939422A

  公开（公告）日：1999-08-17
• US6319928B1
  申请人：——

  公开号：US6319928B1

  公开（公告）日：2001-11-20