(i-丙基)-(2,2-二甲基-4-戊烯基)胺 | 1015419-66-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (i-丙基)-(2,2-二甲基-4-戊烯基)胺
• 英文名称: (i-propyl)-(2,2-dimethyl-4-pentenyl)amine
• 英文别名: 2,2-dimethyl-N-propan-2-ylpent-4-en-1-amine
• CAS: 1015419-66-5
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: RIXRNRDXTBNSOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (i-丙基)-(2,2-二甲基-4-戊烯基)胺 在 C₄₀H₅₀I₄Ir₂N₈ 作用下， 以 氘代苯 为溶剂， 反应 16.0h， 生成 N-isopropyl-2,2-dimethylpent-3-en-1-amine 、 2,4,4-trimethyl-1-(isopropyl)pyrrolidine
  参考文献：
  名称：

  Air- and Water-Stable Catalysts for Hydroamination/Cyclization. Synthesis and Application of CCC−NHC Pincer Complexes of Rh and Ir

  摘要：

  The scope of CCC-NHC pincer complex synthetic methodology by metalation/transmetalation has been extended to Ir. Structural characterization revealed that it is isomorphous with the Rh complex. Both Rh and Ir complexes are efficient catalysts for the hydroamination/cyclization of secondary amines in the presence of air and/or water.

  DOI：

  10.1021/ol8000766
• 作为产物：
  描述：

  2,2-dimethyl-1-amino-pent-4-ene 、 丙酮 在 sodium tetrahydroborate 作用下， 以37%的产率得到(i-丙基)-(2,2-二甲基-4-戊烯基)胺
  参考文献：
  名称：

  Air- and Water-Stable Catalysts for Hydroamination/Cyclization. Synthesis and Application of CCC−NHC Pincer Complexes of Rh and Ir

  摘要：

  The scope of CCC-NHC pincer complex synthetic methodology by metalation/transmetalation has been extended to Ir. Structural characterization revealed that it is isomorphous with the Rh complex. Both Rh and Ir complexes are efficient catalysts for the hydroamination/cyclization of secondary amines in the presence of air and/or water.

  DOI：

  10.1021/ol8000766

文献信息

• Potassium Channel Inhibitors
  申请人：Dinsmore J. Christoph

  公开号：US20080090794A1

  公开（公告）日：2008-04-17

  The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

  本发明涉及具有以下结构的化合物，用作钾通道抑制剂，用于治疗心律失常等。
• US7879839B2
  申请人：——

  公开号：US7879839B2

  公开（公告）日：2011-02-01
• Air- and Water-Stable Catalysts for Hydroamination/Cyclization. Synthesis and Application of CCC−NHC Pincer Complexes of Rh and Ir
  作者：Eike B. Bauer、G. T. Senthil Andavan、T. Keith Hollis、Ramel J. Rubio、Joon Cho、Glenn R. Kuchenbeiser、Theodore R. Helgert、Christopher S. Letko、Fook S. Tham

  DOI：10.1021/ol8000766

  日期：2008.3.1

  The scope of CCC-NHC pincer complex synthetic methodology by metalation/transmetalation has been extended to Ir. Structural characterization revealed that it is isomorphous with the Rh complex. Both Rh and Ir complexes are efficient catalysts for the hydroamination/cyclization of secondary amines in the presence of air and/or water.