(乙基氨基)-乙腈 | 24426-40-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (乙基氨基)-乙腈
• 中文别名: 2-(乙胺基)乙腈
• 英文名称: N-(cyanomethyl)ethylamine
• 英文别名: N-ethylaminoacetonitrile；ethylaminoacetonitrile；Acetonitrile, (ethylamino)-；2-(ethylamino)acetonitrile
• CAS: 24426-40-2
• 化学式: C₄H₈N₂
• mdl: MFCD00137985
• 分子量: 84.1209
• InChiKey: VXAOLDZFARINGE-UHFFFAOYSA-N

物化性质

• 沸点：
  41-42 °C(Press: 3 Torr)
• 密度：
  0.869±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  (乙基氨基)-乙腈 240.0~300.0 ℃ 、0.13 Pa 条件下， 生成 N-乙基甲亚胺
  参考文献：
  名称：

  快速真空热解α-氨基腈并随后在固体碱上去除HCN，这是反应性N-亚甲基胺的“一线”多步骤序列

  摘要：

  通过快速真空热解α-氨基腈并随后在固体碱上除去HCN，在低温下以冷凝状态分离出带有烷基或官能团的反应性亚甲基胺。

  DOI：

  10.1039/c39850000951
• 作为产物：
  描述：

  乙胺 生成 (乙基氨基)-乙腈
  参考文献：
  名称：

  Bleach and oxidation catalyst

  摘要：

  公开号：

  EP1001009B1

文献信息

• Reactions of α-Aminoacetonitriles with Isothiocyanates. Synthesis of 1,3-Disubstituted 5-Imino-2-thiohydantoins
  作者：Takeshi Kinoshita、Hiroko Watanabe、Sadao Sato、Chihiro Tamura

  DOI：10.1246/bcsj.53.442

  日期：1980.2

  The reactions of α-aminoacetonitriles with isothiocyanates gave 1-cyanomethyl-1,3-disubstituted thioureas or 1,3-disubstituted 4-amino-4-imidazoline-2-thiones depending upon the reaction conditions. In the presence of polar organic solvents such as methanol the former products were easily cyclized to the latter. 1,3-Disubstituted 4-amino-4-imidazoline-2-thiones were autoxidized in methanol affording 1,3-disubstituted 5-imino-2-thiohydantoins.

  α-氨基乙腈与异硫氰酸酯的反应可以在不同条件下得到1-氰甲基-1,3-二取代硫脲或1,3-二取代4-氨基-4-咪唑啉-2-硫酮。在极性有机溶剂如甲醇的存在下，前者产物容易环化为后者。1,3-二取代4-氨基-4-咪唑啉-2-硫酮在甲醇中自动氧化生成1,3-二取代5-亚氨基-2-硫脲。
• Studies on anti-Fusarium disease activity of aminonitrile derivatives. I. Preventive activities of N-substituted-.ALPHA.-aminonitriles against Fusarium diseases.
  作者：Osamu KIRINO、Hirofumi OSHITA、Tadashi OISHI、Toshiro KATO

  DOI：10.1271/bbb1961.44.25

  日期：——

  Forty nine N-substituted-α-aminonitriles were prepared and their preventive activities against Fusarium diseases were determined. Relationships between chemical structure and preventive activity were examined and the systemic movement in plants was investigated with 14C-N-allylaminoacetonitrile. Of the compounds tested, N-sec-butyl-α-aminoisobutyronitrile and N-allylaminoacetonitrile were most effective in controlling yellows of the Japanese radish which were caused by Fusarium oxvsporum f. sp. raphani. N-Allylaminoacetonitrile showed remarkable systemic movement and a potent preventive activity against Fusarium wilts of cucumber and tomato not only by the soil drench test but also by the foliar spray assay.

  制备了49种代N-取代-α-氨基腈，并测定了它们对镰刀菌病害的防治活性。研究了化学结构与防治活性之间的关系，并使用14C-N-烯丙基氨基乙腈研究了其在植物中的系统运动。在测试的化合物中，N-仲丁基-α-氨基异丁腈和N-烯丙基氨基乙腈对由尖孢镰刀菌萝卜专化型引起的日本萝卜黄化病具有最佳的防治效果。N-烯丙基氨基乙腈显示出卓越的系统运动，对黄瓜和番茄的镰刀菌萎蔫病不仅通过土壤浸渍测试，还通过叶面喷雾法表现出强效的预防活性。
• Synthesis of a new series of<i>N</i>-substituted-3-[l-alkyl(aryl)- 4-piperidyl]azetidin-2-ones as possible muscarinic agents
  作者：Giorgio Cignarella、Stefania Villa、Daniela Barlocco

  DOI：10.1002/jhet.5570300526

  日期：1993.10

  A new series of N-substituted-3-[1-alkyl(aryl)-4-piperidyl]azetidin-2-ones 2a-j structurally related to the previously reported 2,7-diazaspiro[3.5]nonan-1-ones 1 have been synthesized and tested for their activity as muscarinic agents, both in vitro and in vivo. Preliminary pharmacological results showed that compounds 2 are devoid of significant cholinergic properties.

  与先前报道的2,7-二氮杂螺[3.5] nonan-1-one 1结构相关的一系列新的N-取代-3- [1-烷基（芳基）-4-哌啶基]氮杂环丁烷-2-ones 2a-j 1已经合成并测试了它们在体外和体内作为毒蕈碱剂的活性。初步药理结果表明，化合物2没有明显的胆碱能特性。
• Synthese d'imines lineaires non-stabilisees par reactions gaz-solide sous vide(1)
  作者：Jean-Claude Guillemin、Jean-Marc Denis

  DOI：10.1016/s0040-4020(01)86145-7

  日期：1988.1
• 904. The colour of organic compounds. Part VI. A comparison of isomeric dyes from 3-alkyl-2-thiothiazolid-4- and -5-ones
  作者：R. A. Jeffreys、E. B. Knott

  DOI：10.1039/jr9520004632

  日期：——