1-Palmitoyl-3-oleoyl-sn-glycero-2-PE

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1-Palmitoyl-3-oleoyl-sn-glycero-2-PE
• 英文别名: 2-azaniumylethyl [(2R)-1-hexadecanoyloxy-3-[(Z)-octadec-9-enoyl]oxypropan-2-yl] phosphate
• 化学式: C39H76NO8P
• 分子量: 718.0
• InChiKey: BLMYNJDXEOSYBR-OTMQOFQLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  49
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] LIPIDS SUITABLE FOR NUCLEIC ACID DELIVERY<br/>[FR] LIPIDES APPROPRIÉS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：UNIV RAMOT

  公开号：WO2022168085A1

  公开（公告）日：2022-08-11

  The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

  本发明提供了脂质和脂质纳米粒子配方，包括这些脂质，单独或与其他脂质结合。这些脂质纳米粒子可以与核酸配方，以促进它们在体外和治疗应用中的细胞内传递。本发明还提供了这些脂质的化学合成方法、脂质纳米粒子制备和核酸配方的制备方法。
• Liposomal formulations for delivery of nucleic acids
  申请人：RAMOT AT TEL-AVIV UNIVERSITY LTD.

  公开号：US10583084B2

  公开（公告）日：2020-03-10

  There are provided liposomes, comprising cationic lipids, a membrane stabilizing lipid and at least one lipid conjugated to a polyethylene glycol (PEG) derivative, in particular PEG-amine, the liposomes are coated with a glycosaminoglycan, in particular, Hyaluronic Acid (HA), compositions comprising the same, methods for their preparation and uses thereof for the efficient delivery of nucleic acids, such as, si RNA molecules and for treating various conditions, such as cancer.

  本文提供了脂质体，包括阳离子脂质、膜稳定脂质和至少一种与聚乙二醇（PEG）衍生物（尤其是 PEG-胺）共轭的脂质，脂质体上包被有糖胺聚糖（尤其是透明质酸（HA）），还提供了包含上述脂质体的组合物、其制备方法及其在有效传递核酸（如 si RNA 分子）和治疗各种疾病（如癌症）方面的用途。
• Targeted lipid particles for systemic delivery of nucleic acid molecules to leukocytes
  申请人：RAMOT AT TEL-AVIV UNIVERSITY LTD.

  公开号：US10920246B2

  公开（公告）日：2021-02-16

  Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.

  本发明公开了用于向白细胞（如 T 细胞和 B 细胞）传递核酸分子（如 siRNA）的靶向脂质颗粒。还公开了靶向脂质颗粒用于治疗白细胞相关疾病（如癌症）的用途。
• LIPIDATED GLYCOSAMINOGLYCAN PARTICLES FOR THE DELIVERY OF NUCLEIC ACIDS
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：EP2839015B1

  公开（公告）日：2020-04-29
• LIPOSOMAL FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：EP3160448A1

  公开（公告）日：2017-05-03