1,1'-(2-(N-2-羟基乙基-2-羟基丙基氨基)乙基亚胺)二丙-2-醇 | 139-90-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,1'-(2-(N-2-羟基乙基-2-羟基丙基氨基)乙基亚胺)二丙-2-醇
• 中文别名: 1,1'-(2-(N-2-羟乙基-2-羟丙基氨基)乙基亚胺)二丙-2-醇
• 英文名称: 1,1'-[N-(2-hydroxy-ethyl)-N'-(2-hydroxy-propyl)-N,N'-ethane-1,2-diyl-diamino]-bis-propan-2-ol
• 英文别名: N-(2-hydroxy-ethyl)-N,N',N'-tris-(2-hydroxy-propyl)-ethylenediamine；N-(2-Hydroxy-aethyl)-N,N',N'-tris-(2-hydroxy-propyl)-aethylendiamin；1,1'-[2-(N-2-hydroxyethyl-2-hydroxypropylamino)ethylimino]dipropan-2-ol；N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-N',N'-bis-(2-hydroxypropyl)ethylene diamine；hydroxyethyl-tris-(2-hydroxypropyl)ethylenediamine；N-<2-Hydroxy-aethyl>-N,N'N'-tris<2-hydroxy-propyl>-aethylendiamin；Nalco L-699；1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxyethyl)amino]propan-2-ol
• CAS: 139-90-2
• 化学式: C₁₃H₃₀N₂O₄
• 分子量: 278.392
• InChiKey: VUTCGUXQNADIRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1'-(2-(N-2-羟基乙基-2-羟基丙基氨基)乙基亚胺)二丙-2-醇 、 苯硼酸 生成 diptych-Boroxazilidin von N,N,N'-Tris-<2-hydroxy-propyl>-N'-<2-hydroxyaethyl>-aethylendiamin
  参考文献：
  名称：

  Psarras,T.G. et al., Justus Liebigs Annalen der Chemie, 1962, vol. 655, p. 48 - 54

  摘要：

  DOI：
• 作为产物：
  描述：

  羟乙基乙二胺 、 methyloxirane 生成 1,1'-(2-(N-2-羟基乙基-2-羟基丙基氨基)乙基亚胺)二丙-2-醇
  参考文献：
  名称：

  Diamine derivatives containing hydroxyalkyl groups

  摘要：

  公开号：

  US02884459A1

文献信息

• WATER-STABLE COMPOUNDS, CATALYSTS AND CATALYSED REACTIONS
  申请人：Tulloch Arran Alexander Dickon

  公开号：US20100292449A1

  公开（公告）日：2010-11-18

  The invention provides a method of carrying out a Lewis-acid catalysed organic reaction in the presence of a Lewis acid catalyst comprising a metal-organic compound having the following formula: M(HO(CR 1 R 2 )z)a(O(CR 1 R 2 )z)bY—(CR 3 R 4 )χ-Y((CR 1 R 2 )zO)c((CR 1 R 2 )zOH)d.nR 5 OH (Formula I) in which: M is a metal atom, preferably titanium, zirconium, hafnium or iron (III) Y is selected from P and N, but Ss very preferably N; each R 1 , R 2 , R 3 and R 4 is independently selected from H, alkyl, aryl, substituted alkyl or substituted aryl, R 5 is hydrogen, an alkyl group, a hydroxy-functionalised alkyl group, a polyoxyalkylmoiety, R 6 O or R 7 COO where R 6 and R 7 may each represent H, alkyl, aryl or alkyl-aryl; d and a are each O or 1, b and c are each 1 or 2, b+c=the valency of M, a+b+c+d=4, each z is independently 1, 2, 3 or 4; x represents the least number of C atoms between the Y atoms and is 2 or 3 and n is a number in the range from 0 to 4. The metal-organic compound forms a stable hydrate in water which retains Lewis-acid catalytic properties.

  本发明提供了一种在存在Lewis酸催化剂的情况下进行Lewis酸催化的有机反应的方法，该Lewis酸催化剂包括具有以下公式的金属有机化合物：M(HO(CR1R2)z)a(O(CR1R2)z)bY—(CR3R4)χ-Y((CR1R2)zO)c((CR1R2)zOH)d.nR5OH（公式I），其中：M是金属原子，优选钛、锆、铪或铁(III)；Y选自P和N，但非常优选N；每个R1、R2、R3和R4独立地选自H、烷基、芳基、取代烷基或取代芳基；R5是氢、烷基、羟基功能化的烷基、聚氧烷基部分、R6O或R7COO，其中R6和R7各自可以代表H、烷基、芳基或烷基芳基；d和a各自是O或1，b和c各自是1或2，b+c等于M的价，a+b+c+d=4，每个z独立地是1、2、3或4；x代表Y原子之间最少的C原子数，是2或3，n是0到4之间的数。金属有机化合物在水中形成稳定的含水物，保留了Lewis酸催化性质。
• Solid zirconium-based cross-linking agent and use in oil field applications
  申请人：Putzig Donald Edward

  公开号：US20090131284A1

  公开（公告）日：2009-05-21

  A solid zirconium cross-linking agent is prepared comprising zirconium and hydroxyalkylated ethylene diamine ligand. Use of the cross-linking agent in compositions for oil field applications such as hydraulic fracturing and plugging of permeable zones is also disclosed.

  制备了一种固体锆交联剂，包括锆和羟基烷基化乙二胺配体。还公开了在油田应用中使用交联剂的方法，例如在水力压裂和封堵渗透层的组合物中使用。
• Solid Zirconium-Based Cross-Linking Agent and Use in Oil Field Applications
  申请人：PUTZIG Donald Edward

  公开号：US20120012316A1

  公开（公告）日：2012-01-19

  A solid zirconium cross-linking agent is prepared comprising zirconium and hydroxyalkylated ethylene diamine ligand. Use of the cross-linking agent in compositions for oil field applications such as hydraulic fracturing and plugging of permeable zones is also disclosed.

  制备了一种固体锆交联剂，其中包括锆和羟基烷基化乙二胺配体。还公开了在油田应用中使用交联剂的方法，例如水力压裂和堵塞渗透层。
• Methods of performing medical procedures that promote bone growth, methods of making compositions that promote bone growth, and apparatus for use in such methods
  申请人：Doctor's Research Group, Inc.

  公开号：EP2801376A1

  公开（公告）日：2014-11-12

  Methods of performing medical procedures, and methods of making bone-growth-promoting compositions useful in performing medical procedures are provided. Apparatus useful both in methods of performing medical procedures, and in methods of making bone-growth-promoting compositions useful in performing medical procedures, are provided. The bone-growth-promoting compositions made according to the disclosed methods are biocompatible, and are adapted to stimulate bone growth when positioned in contact with, or in the vicinity of, a bone of a mammal.

  本发明提供了执行医疗程序的方法以及在执行医疗程序中使用的促进骨骼生长组合物的制造方法。本发明提供了可用于执行医疗程序的方法和可用于执行医疗程序的促进骨生长组合物的制作方法的仪器。根据所公开的方法制成的骨生长促进组合物具有生物相容性，当与哺乳动物的骨骼接触或在其附近放置时，可刺激骨骼生长。
• Multi-putty adhesive and cement compositions for tissue hemostasis, repair and reconstruction
  申请人：Abyrx, Inc.

  公开号：US11116866B2

  公开（公告）日：2021-09-14

  The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.

  本公开涉及以聚氨酯和聚脲烷为基础的腻子组合物，这些组合物在室温和体温下硬化成完全固化的固体形式，适合用作骨水泥、骨替代物、硬组织粘合剂或骨止血剂。