2,3-Bis(tricosa-10,12-diynoyloxy)propoxy(2-(trimethylammonio)ethoxy)phosphinic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2,3-Bis(tricosa-10,12-diynoyloxy)propoxy(2-(trimethylammonio)ethoxy)phosphinic acid
• 英文别名: 2-[2,3-di(tricosa-10,12-diynoyloxy)propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C54H93NO8P+
• 分子量: 915.3
• InChiKey: IDBJTPGHAMAEMV-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  17.4
• 重原子数：
  64
• 可旋转键数：
  46
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Separation Medium for Biochemical Analysis
  申请人：Masuda Mitsutoshi

  公开号：US20090211907A1

  公开（公告）日：2009-08-27

  The invention provides a novel packing composition for separation and/or analysis which permits easy capillary replacement; a process for the production of the packing composition; a method for filling a capillary with the packing composition; and electrophoretic methods (such as capillary electrophoresis) with the same. The invention relates to a packing composition for electrophoretic separation and/or analysis which contains a long self-assembly produced by dissolving a low-molecular-weight amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety in water under heating and then cooling the resulting solution; a process for the production of the packing composition; a method of separation and/or analysis with the composition; and so on.

  本发明提供了一种新型的用于分离和/或分析的填充组合物，可以轻松更换毛细管；生产填充组合物的方法；用填充组合物填充毛细管的方法；以及使用相同的电泳方法（如毛细管电泳）。本发明涉及一种用于电泳分离和/或分析的填充组合物，其包含通过将具有疏水部分和亲水部分的低分子量两亲性化合物在加热水中溶解然后冷却所得的长链自组装体；生产填充组合物的方法；使用该组合物进行分离和/或分析的方法等。
• PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：EP3019201B1

  公开（公告）日：2020-03-18
• METHODS OF NANOSCALE DIRECTIONAL WETTING AND USES THEREOF
  申请人：Purdue Research Foundation

  公开号：US20200061667A1

  公开（公告）日：2020-02-27

  This invention discloses a method for controlling nanoscopic wetting near or at a molecular scale for synthetic material applications. In particular this invention relates to a method for preparing a monolayer or thin film with a patterned nanoscopic wetting surface using a ‘sitting’ phase of polymerizable amphiphile, wherein hydrophobic alkyl chains of the amphiphile extend along the supporting surface and the amphiphile molecules align side-to-side, effectively forming a repeating cross-section of bilayer with alternating hydrophilic and hydrophobic stripes of a ˜6 nm pitch tunable based on the chain length of the amphiphile. Products prepared according to the methods disclosed herein are within the scope of this invention. In some embodiments, monolayers or thin films so prepared are transferable.
• A LIPID-BASED COATING COMPOSITION, AND AN OBJECT HAVING A LIPID-BASED COATING
  申请人：LIPOCOAT B.V.

  公开号：US20200405641A1

  公开（公告）日：2020-12-31

  A lipid-based coating composition for coating a medical device, wherein the coating composition includes a) lipid vesicles consisting of i. 85-95 mol % of a phospholipid (A) having a phosphatidylcholine group; ii. 5-12 mol % of a PEGylated phospholipid (B); optionally 0-3 mol % of a lipophilic compound (C) other than lipids (A) and (B); b) 0-5 wt. % of a water-soluble additive (D); and c) at least 95 wt. % of water, wherein lipid vesicles having a number average size between 50 and 140 nm (measured according to dynamic light scattering) and wherein the lipid vesicle concentration ranges between 0.025 mg/ml and 2 mg/ml, and wherein the mol % of lipids (A), (B) and (C) is calculated relative to the total molar amount of lipids (A)+(B)+(C) in the lipid-based coating composition and wherein the wt. % of water-soluble additive (D) is calculated relative to the weight of the total composition. Preferably the medical device is a contact lens, a catheter or a medical implant.
• US8294007B2
  申请人：——

  公开号：US8294007B2

  公开（公告）日：2012-10-23