1,1,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-十六氟-2-(三氟甲基)十氢异喹啉 | 86714-34-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,1,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-十六氟-2-(三氟甲基)十氢异喹啉
• 英文名称: Perfluoro-N-methyldecahydroisoquinoline
• 英文别名: 1,1,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-hexadecafluoro-2-(trifluoromethyl)isoquinoline
• CAS: 86714-34-3
• 化学式: C₁₀F₁₉N
• 分子量: 495.08
• InChiKey: MRQNKLRMROXHTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  1,1,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-十六氟-2-(三氟甲基)十氢异喹啉 、 三氧化硫 以27%的产率得到
  参考文献：
  名称：

  ABE, TAKASHI;HAYASHI, EIJI;MURAMATSU, HIROSHIGE;OKAZAKI, HIROSHI;SOEDA, M+

  摘要：

  DOI：

文献信息

• Emulsified preparations containing perfluorocarbon compound
  申请人：THE GREEN CROSS CORPORATION

  公开号：EP0399842A2

  公开（公告）日：1990-11-28

  An emulsified preparation containing a perfluorocarbon compound comprises 5-50% (w/v) of a perfluorocarbon compound represented by the formula: (wherein R represents a lower perfluoroalkyl group), 1-5% (w/v) of a phospholipid, 0.01-0.1% (w/v) of a fatty acid or an ester or a salt thereof, 0.001-0.01% (w/v) of tocopherol, 0.011-1.1% (w/v) of a pH adjuster, and an adequate amount of an aqueous solvent. This emulsified preparation can be used as an oxygen-carrying infusion fluid or perfusion fluid for preserving organs.

  一种含有全氟碳化合物的乳化制剂由 5-50%（重量/体积）的全氟碳化合物（式中 R 代表低级全氟烷基）、1-5%（重量/体积）的磷脂、0.01-0.1%（重量/体积）的脂肪酸或酯或脂质组成： (其中 R 代表低级全氟烷基）、1-5%（重量/体积）的磷脂、0.01-0.1%（重量/体积）的脂肪酸或其酯或盐、0.001-0.01%（重量/体积）的生育酚、0.011-1.1%（重量/体积）的 pH 值调节剂和适量的水性溶剂。这种乳化制剂可用作保存器官的携氧输液或灌注液。
• Internal organ-preserving liquid and method for preserving internal organs
  申请人：THE GREEN CROSS CORPORATION

  公开号：EP0440925A1

  公开（公告）日：1991-08-14

  Organ-preserving liquids comprising, as an active ingredient, an undiluted liquid of a perfluorocarbon compound or an emulsion containing the same at a high concentration and methods for preserving internal organs are disclosed. The internal organ-preserving liquids of the present invention are extremely useful in the clinical situations as organ-preserving liquids in organ transplantation for mammals including humans, especially as preserving liquids for internal organs having likelihood of thermal ischemic disorders. According to the present invention, internal organs (e.g. pancreas, liver) are preserved by immersing the internal organs in an undiluted liquid of a perfluorocarbon or an emulsion thereof at a high concentration, preferably, with oxygen bubbling.

  本发明公开了由未稀释的全氟碳化合物液体或含有高浓度全氟碳化合物的乳液作为活性成分的器官保存液以及保存内脏器官的方法。本发明的内脏器官保存液作为哺乳动物（包括人类）器官移植中的器官保存液在临床上非常有用，特别是作为有可能发生热缺血性疾病的内脏器官的保存液。 根据本发明，将内脏器官（如胰腺、肝脏）浸泡在未稀释的高浓度全氟碳化合物或其乳液中，最好伴有氧气气泡，从而保存内脏器官。
• EXTENDING TISSUE PRESERVATION
  申请人：——

  公开号：US20010055809A1

  公开（公告）日：2001-12-27

  A method of preserving tissue by placing the tissue in a media containing pure perfluorocarbon is provided. Also provided is a tissue preserving media including storage media and pure perfluorocarbon. A method of making media by adding pure perfluorocarbon to the media is provided. A method of preserving tissue by oxygenating the storage media by adding pure perfluorocarbons to the media is also provided.

  本研究提供了一种通过将组织置于含有纯全氟碳化物的介质中来保存组织的方法。还提供了一种组织保存介质，包括储存介质和纯全氟碳化物。还提供了一种通过向介质中添加纯全氟碳化物来制作介质的方法。还提供了一种通过向储存介质中添加纯全氟碳化物使其充氧来保存组织的方法。
• Extending tissue preservation
  申请人：——

  公开号：US20020103222A1

  公开（公告）日：2002-08-01

  A method of preserving tissue by placing the tissue in a media containing pure perfluorocarbon is provided. Also provided is a tissue preserving media including storage media and pure perfluorocarbon. A method of making media by adding pure perfluorocarbon to the media is provided. A method of preserving tissue by oxygenating the storage media by adding pure perfluorocarbons to the media is also provided.

  本研究提供了一种通过将组织置于含有纯全氟碳化物的介质中来保存组织的方法。还提供了一种组织保存介质，包括储存介质和纯全氟碳化物。还提供了一种通过向介质中添加纯全氟碳化物来制作介质的方法。还提供了一种通过向储存介质中添加纯全氟碳化物使其充氧来保存组织的方法。
• HAYASHIH, EIJI;SOEDA, MAHITO;OKAZAKI, HIROSHI;ABE, TAKASHI, CHEM. EXPRESS., 3,(1988) N, C. 371-374
  作者：HAYASHIH, EIJI、SOEDA, MAHITO、OKAZAKI, HIROSHI、ABE, TAKASHI

  DOI：——

  日期：——