1,10-癸二胍硫酸盐

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,10-癸二胍硫酸盐
• 中文别名: 合成靈；1,10-癸二胍鹽酸鹽；十亚甲基双胍二盐酸盐；双盐酸癸双胍；新塔林；合成灵
• 英文名称: 2-[10-(diaminomethylideneamino)decyl]guanidine;hydron;dichloride
• 化学式: C12H30Cl2N6
• 分子量: 329.31
• InChiKey: HJJOBGICUREWHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  129
• 氢给体数：
  6
• 氢受体数：
  2

文献信息

• INTRANASAL ADMINISTRATION OF PHARMACEUTICAL AGENTS FOR TREATMENT OF NEUROLOGICAL DISEASES
  申请人：Wong Patrick S L

  公开号：US20140100282A1

  公开（公告）日：2014-04-10

  Pharmaceutical formulations for treating neurological diseases are described, wherein the formulations comprise a pharmaceutically active agent-transport moiety complex. The formulations are suitable for administration via an intranasal route. Neurological diseases and conditions are associated with reduced brain insulin signaling (i.e., CNS insulin insensitivity), reduced dopaminergic signaling, reduced serotonergic signaling, reduced cholinergic signaling, or reduced GABAergic signaling, and include Alzheimer's disease, Parkinson's disease, epilepsy, neuropathic pain, fibromyalgia, post-herpetic neuralgia, insomnia, or anxiety. Neurological diseases also include cancers of the central nervous system (CNS).

  本文描述了用于治疗神经系统疾病的制药配方，其中包含药物活性剂-转运基团复合物。这些配方适合经鼻给药途径。神经系统疾病和病情与降低的脑内胰岛素信号（即中枢神经系统胰岛素不敏感性）、降低的多巴胺信号、降低的血清素信号、降低的乙酰胆碱信号或降低的GABA能信号有关，包括阿尔茨海默病、帕金森病、癫痫、神经痛、纤维肌痛、带状疱疹后神经痛、失眠或焦虑。神经系统疾病还包括中枢神经系统（CNS）的癌症。
• Treatment of Subterranean Formations
  申请人：Murphy Christopher B.

  公开号：US20120160485A1

  公开（公告）日：2012-06-28

  A method of preparing and using a subterranean formation stabilization agent. The stabilization agent includes a guanidyl copolymer and may be admixed with a fracturing fluid and optionally brine. The stabilization agent is effective in preventing and/or reducing, for example, clay swelling and fines migration from a subterranean formation contacted with the stabilization agent.
• US8220565B1
  申请人：——

  公开号：US8220565B1

  公开（公告）日：2012-07-17
• US8631868B1
  申请人：——

  公开号：US8631868B1

  公开（公告）日：2014-01-21