1,2,3-苯并三嗪-4-胺 | 89795-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并-1,2,3-三嗪类化合物
• 中文名称: 1,2,3-苯并三嗪-4-胺
• 英文名称: 4-aminobenzo-1,2,3-triazine
• 英文别名: 4-Amino-benzo-1.2.3-triazin；benzo[1,2,3]triazin-4-ylamine；benzo[d][1,2,3]triazin-4-ylamine；1,2,3-Benzotriazin-4-amine
• CAS: 89795-80-2
• 化学式: C₇H₆N₄
• mdl: MFCD11557187
• 分子量: 146.151
• InChiKey: KFTFNTPGDZCQSP-UHFFFAOYSA-N

物化性质

• 熔点：
  284-285 °C(Solv: ethanol (64-17-5))
• 沸点：
  376.3±34.0 °C(Predicted)
• 密度：
  1.385±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933699090

反应信息

• 作为产物：
  描述：

  3-氨基吲唑 在 sodium hydroxide 、 氯仿 、 sodium hydroxylamine-O-sulfonate 作用下， 以 乙醇 为溶剂， 反应 721.33h， 生成 1,2,3-苯并三嗪-4-胺
  参考文献：
  名称：

  摘要：

  DOI：

  10.1023/a:1011600420626

文献信息

• [EN] SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYPE QUINOXALINES ET BENZOTRIAZINE SUBSTITUÉES DE LA P70S6 KINASE
  申请人：SENTINEL ONCOLOGY LTD

  公开号：WO2016170163A1

  公开（公告）日：2016-10-27

  The invention provides compounds that inhibit or modulate the activity of p70S6 kinase, the compounds being of the formula (0), or a salt, tautomer or N-oxide thereof; wherein: X1 is N or N+(0-); X2 is N or CH; Q1 is an optionally substituted C1-8 alkylene; Q2 is a bond or an optionally substituted C1-8 alkylene group; R1 is selected from hydrogen and a group Cy1; Cy1 is an optionally substituted 4 to 7 membered monocyclic non-aromatic carbocyclic or heterocyclic group containing 0, 1 or 2 heteroatom ring members selected from O and S and oxidised forms of S; R2, R3 and R4 are the same or different and each is selected from hydrogen, fluorine, chlorine, C1-2 alkyl and C1-2 alkoxy, wherein each C1-2 alkyl and C1-2 alkoxy is optionally substituted with two or more fluorine atoms; Ar1 is an optionally substituted monocyclic 5 or 6-membered aryl or heteroaryl ring containing 0, 1 or 2 heteroatom ring members selected from O, N and S, or a naphthyl ring Ar2 is an optionally substituted bicyclic 8 to 1 1 -membered heteroaryl group containing 1, 2, 3 or 4 heteroatom ring members selected from O, N and S. The compounds are useful in medicine, for example in the treatment of a disease or condition selected from cancers (e.g. triple negative breast cancer, brain tumours and brain metastases arising from non-brain cancers), neurodevelopmental diseases (e.g. Fragile X syndrome) and neurodegenerative diseases.

  该发明提供了抑制或调节p70S6激酶活性的化合物，该化合物的结构如下式（0），或其盐、互变异构体或N-氧化物；其中：X1为N或N+(0-)；X2为N或CH；Q1为可选择取代的C1-8烷基；Q2为键或可选择取代的C1-8烷基基团；R1选自氢和Cy1基团；Cy1为可选择取代的含有0、1或2个来自O和S的杂原子环成员的4到7成员单环非芳香碳环或杂环基团及S的氧化形式；R2、R3和R4相同或不同，每个选自氢、氟、氯、C1-2烷基和C1-2烷氧基，其中每个C1-2烷基和C1-2烷氧基可选择地取代为两个或更多氟原子；Ar1为可选择取代的含有0、1或2个来自O、N和S的杂原子环成员的单环5或6成员芳基或杂芳基环，或一个萘环；Ar2为可选择取代的含有1、2、3或4个来自O、N和S的杂原子环成员的双环8到11成员杂芳基基团。这些化合物在医学上有用，例如在治疗癌症（如三阴性乳腺癌、脑肿瘤和来自非脑部癌症的脑转移瘤）、神经发育疾病（如脆性X综合征）和神经退行性疾病等疾病或病况的治疗中。
• FLAME-RETARDANT RESIN COMPOSITION FOR TRANSMISSION SIDE MEMBER IN LASER WELDING
  申请人：Wintech Polymer Ltd.

  公开号：EP1967549A1

  公开（公告）日：2008-09-10

  A laser-weldable flame-retardant resin composition (for a member located in a transmitting side) comprises (A) a polyester-series resin and (B) at least one phosphinic acid compound selected from the group consisting of a salt of a phosphinic acid, a salt of a diphosphinic acid, and a polymer thereof (preferably, a metal salt). The resin composition may have a laser light transmittance of not less than 15% for a molded product comprising the resin composition and having a thickness of 2 mm. The resin composition may further contain a fluorine-containing resin, a nitrogen-containing flame retardant (e.g., a salt of a triazine compound with cyanuric acid and/or isocyanuric acid), and/or a filler (e.g., a glass fiber), and others. Such a resin composition realizes both of laser-weldability (laser transmissivity) and flame retardancy at high levels.

  一种可激光焊接的阻燃树脂组合物（用于位于透射侧的部件）包括（A）聚酯系列树脂和（B）至少一种膦酸化合物，该化合物选自由膦酸盐、二膦酸盐及其聚合物（最好是金属盐）组成的组。对于包含该树脂组合物且厚度为 2 毫米的模塑产品，该树脂组合物的激光透光率可不低于 15%。该树脂组合物还可进一步含有含氟树脂、含氮阻燃剂（如三嗪化合物与氰尿酸和/或异氰尿酸的盐）和/或填料（如玻璃纤维）等。这样的树脂组合物可实现高水平的激光焊接性（激光透过率）和阻燃性。
• FLAME-RETARDANT POLYBUTYLENE TEREPHTHALATE RESIN COMPOSITION, AND MOLDED PRODUCT THEREOF
  申请人：Wintech Polymer Ltd.

  公开号：EP2927279A1

  公开（公告）日：2015-10-07

  Provided are: a flame-retardant polybutylene terephthalate resin composition which exhibits excellent flame retardance, glow-wire properties (GWIT), tracking resistance and bleed resistance in spite of a fact that a polybutylene terephthalate resin is used as a sole resin component; and a molded product of the resin composition. A flame-retardant polybutylene telephthalate resin composition containing (A) a polybutylene telephthalate resin, (B) a phosphinic acid salt, (C) a phosphazene compound, and (D) a nitrogen-containing cyclic compound, which exhibits a flame retardance in accordance with a UL94 flammability test of V-0, a glow-wire ignition temperature (GWIT) in accordance with IEC60695-2-13 standard of 775°C or more, and a comparative tracking index (CTI) in accordance with IEC60112 standard of 400 V or more, and bleed out does not occur when the composition is treated at 110°C for 20 hours.

  本文提供了：一种阻燃性聚对苯二甲酸丁二醇酯树脂组合物，该组合物在使用聚对苯二甲酸丁二醇酯树脂作为唯一树脂成分的情况下仍能表现出优异的阻燃性、萤光丝特性（GWIT）、耐跟踪性和抗渗漏性；以及该树脂组合物的模塑产品。一种阻燃性聚对苯二甲酸丁二醇酯树脂组合物，含有(A)聚对苯二甲酸丁二醇酯树脂、(B)膦酸盐、(C)磷苯化合物和(D)含氮环状化合物，其阻燃性能符合 UL94 易燃性测试 V-0、根据 IEC60695-2-13 标准，其辉光丝点火温度（GWIT）为 775°C 或以上，根据 IEC60112 标准，其比较跟踪指数（CTI）为 400 V 或以上，且在 110°C 下处理 20 小时不会发生渗出。
• Flame-retardant resin composition
  申请人：——

  公开号：US20040254270A1

  公开（公告）日：2004-12-16

  A flame-retardant resin composition comprises a thermoplastic resin; a flame retardant comprising a phosphorus-containing compound (A), a aromatic resin (B), and at least one flame-retardant auxiliary (C) selected from a nitrogen-containing compound and a metal salt of an inorganic acid; and at least one stabilizer auxiliary (D) selected from a compound having a functional group reactive to an active hydrogen atom and a water-repellent compound. The phosphorus-containing compound may be a phosphoric ester. The aromatic resin may be a polyphenylene sulfide-series resin or a polyphenylene oxide-series resin. The nitrogen-containing compound is a salt of an amino group-containing triazine compound with an oxygen acid, a salt of an amino group-containing triazine compound with a hydroxyl group-containing triazine compound, a polyphosphoric acid amide, a cyclic urea compound, or others. The present invention provides a flame-retardant resin composition which has been flame-retarded without using a halogen-containing flame retardant.

  阻燃树脂组合物包括热塑性树脂；阻燃剂，包括含磷化合物（A）、芳香族树脂（B）和至少一种阻燃助剂（C），该助剂选自含氮化合物和无机酸的金属盐；以及至少一种稳定助剂（D），该稳定助剂选自具有与活性氢原子反应的官能团的化合物和憎水化合物。含磷化合物可以是磷酸酯。芳香族树脂可以是聚苯硫醚系列树脂或聚苯氧化物系列树脂。含氮化合物为含氨基三嗪化合物与含氧酸的盐、含氨基三嗪化合物与含羟基三嗪化合物的盐、多磷酸酰胺、环状脲化合物或其他。本发明提供了一种不使用含卤素阻燃剂就能阻燃的阻燃树脂组合物。
• Notes- Benzo-1,2,3-triazines
  作者：Christoph Grundmann、Henri Ulrich

  DOI：10.1021/jo01084a641

  日期：1959.2