1,2-二丁基胍 | 34331-58-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,2-二丁基胍
• 英文名称: N,N'-dibutyl-guanidine
• 英文别名: 1,3-dibutyl-guanidine；N,N'-Dibutyl-guanidin；Guanidine, N,N'-dibutyl-；1,2-dibutylguanidine
• CAS: 34331-58-3
• 化学式: C₉H₂₁N₃
• mdl: MFCD20547504
• 分子量: 171.286
• InChiKey: HXEJAEDEMWCUTP-UHFFFAOYSA-N

物化性质

• 熔点：
  36.2 °C
• 沸点：
  122-127 °C(Press: 0.005 Torr)
• 密度：
  0.94±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N'-二正丁基硫脲 在 copper sulphate-silica gel 、 sodium amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.83h， 以80%的产率得到1,2-二丁基胍
  参考文献：
  名称：

  An expedient synthesis of substituted guanidines

  摘要：

  This work discusses a rapid synthesis of substituted guanidines from 1,3-disubstituted thloureas using copper sulphate-silica gel in the presence of an amine. The method surpasses the previous known methods for the synthesis.

  DOI：

  10.1016/0040-4039(95)00360-o

文献信息

• FUNCTIONALIZED HIGHLY BRANCHED MELAMINE-POLYAMINE POLYMERS
  申请人：Peretolchin Maxim

  公开号：US20120252987A1

  公开（公告）日：2012-10-04

  The present invention relates to a method for producing amphiphilic functionalized highly branched melamine-polyamine polymers by condensing melamine and optionally a melamine derivate having at least one different amine having at least two primary amino groups and optionally also with urea and/or at least one urea derivative and/or with at least one at least difunctional diisocyanate or polyisocyanate and/or at least one carbolic acid having at least two carboxyl groups or at least one derivative thereof, optionally quaternizing a portion of the amino groups of the polymer thereby obtained, reacting the polymer thus obtained with at least one compound capable of undergoing a condensation or addition reaction with amino groups, and optionally quaternizing at least part of the amino groups of the polymer obtained in the first step. The invention further relates to the amphiphilic functionalized highly branched melamine-polyamine polymers that can be obtained by the method according to the invention, and to the use thereof as surface active agents.

  本发明涉及一种通过将三聚氰胺和至少一种具有至少两个主要氨基的不同氨基的三聚氰胺衍生物以及可能还包括尿素和/或至少一种尿素衍生物和/或至少一种至少双官能团二异氰酸酯或多异氰酸酯和/或至少一种至少具有两个羧基的羧酸或其衍生物缩合，从而制备含有两性功能化的高支化三聚氰胺-多胺聚合物的方法。可选地，对所获得的聚合物的部分氨基进行季铵化，然后将所获得的聚合物与至少一种能够与氨基发生缩合或加成反应的化合物反应，并可选地对第一步中获得的聚合物的部分氨基进行季铵化。本发明还涉及通过本发明的方法可以获得的含有两性功能化的高支化三聚氰胺-多胺聚合物，以及将其用作表面活性剂的用途。
• Process for preparing chain exteded thermoplastic guanidinium polymers
  申请人：Hall Denise

  公开号：US20050041080A1

  公开（公告）日：2005-02-24

  A process for forming a chain extended thermoplastic polymer which comprises reacting: (i) a prepolymer comprising one or more guanidinium or biguanidinium units and having at least one reactive end group; and (ii) a chain extender having at least two groups able to react with reactive end group(s) in (i). The polymers may be used as fixing agents to reduce highlighter smear of prints prepared by ink jet printing.

  一种制备链延伸热塑性聚合物的方法，包括反应：(i)预聚物，其中包括一个或多个胍盐或双胍盐单元，并具有至少一个反应末端基团;和(ii)链延伸剂，具有至少两个能够与(i)中的反应末端基团反应的基团。这些聚合物可用作固定剂，以减少喷墨打印制备的印刷品的荧光笔晕染。
• NITROGENOUS HETEROCYCLIC COMPOUND AND MEDICINAL USE THEREOF
  申请人：Ochiai Hiroshi

  公开号：US20090233908A1

  公开（公告）日：2009-09-17

  A compound represented by formula (I): (wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medicinal use thereof. The compound represented by formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and/or therapeutic agent for CXCR4-mediated diseases such as inflammatory/immunologic diseases (e.g., rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infections diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease, metabolic diseases, cancer diseases (e.g., cancer, cancer metastasis) or as an agent for regeneration therapy.

  化合物的化学式为（I）：（其中符号的定义与说明书中相同），其盐，N-氧化物，溶剂化合物或前药，以及其药用。化合物（I）具有CXCR4拮抗活性。因此，它可用作预防和/或治疗CXCR4介导疾病的药物，例如炎症/免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化和移植器官的排斥反应），过敏性疾病，感染性疾病（例如人类免疫缺陷病毒感染和获得性免疫缺陷综合症），心理神经疾病，脑部疾病，心血管疾病，代谢性疾病，癌症（例如癌症，癌症转移）或再生治疗剂。
• COMPOUND HAVING CYCLIC GROUP BOUND THERETO THROUGH SPIRO BINDING AND USE THEREOF
  申请人：Hanada Keisuke

  公开号：US20090325992A1

  公开（公告）日：2009-12-31

  A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and/or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.

  化合物的一般式（I）所代表的化合物，其盐、溶剂化物或前药，其中所有符号均如规范中定义的那样，具有对CXCR4的拮抗活性，因此可用作预防和/或治疗CXCR4介导的疾病的药物，例如炎症和免疫性疾病（例如类风湿性关节炎、关节炎、视网膜病变、黄斑变性、肺纤维化、移植器官排斥等）、过敏性疾病、感染（例如人类免疫缺陷病毒感染、获得性免疫缺陷综合症等）、精神神经疾病、脑部疾病、心血管疾病、代谢性疾病、癌症（例如癌症、癌症转移等）的预防和/或治疗药物，或作为再生疗法的药物。
• Process for preparing chain extended thermoplastic guanidinium polymers
  申请人：Fujifilm Imaging Colorants Limited

  公开号：US07172274B2

  公开（公告）日：2007-02-06

  A process for forming a chain extended thermoplastic polymer which includes reacting: (i) a prepolymer having one or more guanidinium or biguanidinium units and having at least one reactive end group; and (ii) a chain extender having at least two groups able to react with reactive end group(s) in (i). The polymer used as fixing agent to reduce highlighter smear of prints prepared by ink jet printing.

  一种形成链延长热塑性聚合物的方法，包括反应：（i）具有一个或多个胍铵或双胍铵单元并具有至少一个反应末端基团的预聚物；以及（ii）具有至少两个能够与（i）中的反应末端基团反应的基团的链延长剂。所述聚合物用作固定剂，以减少喷墨打印制备的印刷品的荧光笔晕染。