1,2-二棕榈酰基-sn-甘油-3-磷酸硫代乙醇(钠盐) | 474923-39-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 中文名称: 1,2-二棕榈酰基-sn-甘油-3-磷酸硫代乙醇(钠盐)
• 英文名称: 1,2-dipalmitoyl-sn-glycero-3-phosphothioethanol
• 英文别名: 16:0 PTE；Sodium (2R)-2,3-bis(hexadecanoyloxy)propyl 2-sulfanylethyl phosphate；sodium;[(2R)-2,3-di(hexadecanoyloxy)propyl] 2-sulfanylethyl phosphate
• CAS: 474923-39-2
• 化学式: C₃₇H₇₂O₈PS*Na
• 分子量: 731.003
• InChiKey: AKETWRINAWSUQU-RUQJKXHKSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  7.84
• 重原子数：
  48
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  、 1,2-二棕榈酰基-sn-甘油-3-磷酸硫代乙醇(钠盐) 以 d-Chloroform 为溶剂， 反应 96.0h， 以95%的产率得到Ma-PTE
  参考文献：
  名称：

  Quantitative Glycomics from Fluidic Glycan Microarrays

  摘要：

  A hallmark of cell-surface processes involving glycans is their multivalent interaction with glycan binding proteins (GBPs). Such a multivalent interaction depends critically on the mobility and density of signaling molecules on the membrane surface. While glycan microarrays have been used in exploring multivalent interactions, the lack of mobility and the difficulty in controlling surface density both limit their quantitative applications. Here we apply a fluidic glycan microarray, with glycan density varying for orders of magnitude, to profile cell surface interaction using a model system, the adhesion of Escherichia coli to mannose. We show the quantitative determination of monovalent and multivalent adhesion channels; the latter can be inhibited by nanopartices presenting a high density of mannosyl groups. These results reveal a new E. coli adhesion mechanism: the switching in the FimH adhesion protein avidity from monovalent to multivalent as the density of mobile mannosyl groups increases; such avidity switching enhances binding affinity and triggers multiple fimbriae anchoring. Affinity enhancement toward FimH has only been observed before for oligo-mannose due to the turn on of secondary interactions outside the mannose binding pocket. We suggest that the new mechanism revealed by the fluidic microarray is of general significance to cell surface interactions: the dynamic clustering of simple sugar groups (homogeneous or heterogeneous) on the fluidic membrane surface may simulate the functions of complex glycan molecules.

  DOI：

  10.1021/ja902783n