Efficient synthesis of 2- and 3-substituted indenes from 2-bromobenzyl bromide through an enolate alkylation/Cr(II)/Ni(II)-mediated carbonyl addition sequence
作者:Ronald L. Halterman、Chengian Zhu
DOI:10.1016/s0040-4039(99)01541-5
日期:1999.10
efficient new synthesis of 2- and 3-substituted indenes has been developed based on the nickel-catalyzed chromium(II)-promoted addition of aryl bromides to a tethered ketone carbonyl. Several tethered bromoaryl ketones were prepared through enolatealkylation of acyclic or cyclic ketones with 2-bromobenzyl bromide. Nozaki-Takai-Hiyama-Kishi closure of the resulting bromoaryl ketones followed by acid promoted
Rhodium(II)- or Copper(I)-Catalyzed Formal Intramolecular Carbene Insertion into Vinylic C(sp<sup>2</sup>
)−H Bonds: Access to Substituted 1<i>H</i>
-Indenes
作者:Qi Zhou、Shichao Li、Yan Zhang、Jianbo Wang
DOI:10.1002/anie.201709375
日期:2017.12.11
A rhodium(II)‐ or copper(I)‐catalyzed formal intramolecular carbene insertion into vinylic C(sp2)−H bonds is reported herein. This method provides straightforward access to 1H‐indenes with high efficiency and excellent functional‐group compatibility. Mechanistically, the reaction is proposed to involve the following sequence: metal carbene formation, intramolecular nucleophilic addition of the double
Some cyclohexadienols, when heated at 220° with PyHCl, gave, through dehydration and isomerisation, the corresponding benzene derivatives. So 2,6-dibenzyliden-cyclohexanols gave m-dibenzyl-benzenes, 2-benzyliden-1-tetralols gave 2-benzyl-naphthalenes and 2,6-dicyclohexenyl cyclohexanols gave m-dicyclohexyl-benzenes. The correlation between these aromatisations and those of cyclohexenone acetic acids
Synthesis of Dihydro‐5<i>H</i>‐Benzo[<i>c</i>]‐Fluorenes, Dihydroindeno[<i>c</i>]‐Chromenes and Thiochromenes<i>via</i>Intramolecular Cyclization and their Effect on Human Leukemia Cells
series of 6,7-dihydro-5H-benzo[c]fluorenes. Their synthesis is based on an intramolecular-cyclization of tricyclic substrates, which has an alcohol functional group in acidic conditions at ambient temperature. Certain reaction optimization conditions reveal that triflic acid was the most convenient reagent for this transformation, affording a broad range of fluorene derivatives in a 37 to 93% yield
在这项工作中,我们描述了一系列 6,7-二氢-5H-苯并[ c ]芴的构建。它们的合成基于三环底物的分子内环化,三环底物在环境温度下的酸性条件下具有醇官能团。某些反应优化条件表明,三氟甲磺酸是该转化最方便的试剂,以 37% 至 93% 的产率提供范围广泛的芴衍生物。我们通过克级合成以及二氢茚并[ c ]-色烯硫色烯和薁烯衍生物的制备来说明该方法的稳健性。
Bangh, Mircea D.; Hada, Catalina; Draghici, Constantin, Revue Roumaine de Chimie, 1994, vol. 39, # 6, p. 645 - 652
作者:Bangh, Mircea D.、Hada, Catalina、Draghici, Constantin、Petride, Aurica、Banciu, Anca