1,3-二甲基-8-异丁基-1H-嘌呤-2,6(3H,7H)-二酮 | 5770-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 1,3-二甲基-8-异丁基-1H-嘌呤-2,6(3H,7H)-二酮
• 英文名称: 8-isobutyl-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione
• 英文别名: 8-isobutyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione；8-Isobutyl-1,3-dimethyl-3,7-dihydro-purin-2,6-dion；8-Isobutyltheophyllin；Theophylline, 8-isobutyl-；1,3-dimethyl-8-(2-methylpropyl)-7H-purine-2,6-dione
• CAS: 5770-30-9
• 化学式: C₁₁H₁₆N₄O₂
• 分子量: 236.274
• InChiKey: NOEMEJJCNDUHJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异戊酸 、 5,6-二氨基-1,3-二甲基脲嘧啶 生成 1,3-二甲基-8-异丁基-1H-嘌呤-2,6(3H,7H)-二酮
  参考文献：
  名称：

  Some Alkyl Homologs of Theophylline

  摘要：

  DOI：

  10.1021/ja01097a032

文献信息

• [EN] CALCIUM DICARBOXYLATE ETHERS, METHODS OF MAKING SAME, AND TREATMENT OF VASCULAR DISEASE AND DIABETES THEREWITH<br/>[FR] ETHERS DE DICARBOXYLATE DE CALCIUM, LEURS PROCEDES DE FABRICATION ET LEUR UTILISATION DANS LE TRAITEMENT DES MALADIES VASCULAIRES ET DU DIABETE
  申请人：WARNER LAMBERT CO

  公开号：WO2001055078A1

  公开（公告）日：2001-08-02

  Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula (I), wherein R1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia.

  6-(5-羧基-5-甲基己氧基)-2,2-二甲基己酸单钙盐的酒精和水溶剂是结晶的，其化学式为（I），其中R1为氢或低碳基，x为0至10的数字，可用于治疗血脂异常。
• Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
  申请人：——

  公开号：US20030119912A1

  公开（公告）日：2003-06-26

  Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexonoic acid monocalcium salt are crystalline and have the formula (I), wherein R 1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia.

  6-(5-羧基-5-甲基己氧基)-2,2-二甲基己酸单钙盐的酒精和水溶剂是结晶的，其化学式为（I），其中R1为氢或低级烷基，x为0至10的数字，可用于治疗血脂异常。
• Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
  申请人：DeveloGen Aktiengesellschaft

  公开号：EP2096120A2

  公开（公告）日：2009-09-02

  This invention relates to the use of secreted SF01-SF13 proteins, to the use of polynucleotides encoding these, and to the use of effectors/modulators thereof in the diagnosis, study, prevention, and treatment of pancreatic diseases (e.g. diabetes mellitus), obesity and/or metabolic syndrome and to the use in regeneration of tissues such as pancreatic tissues and others.

  本发明涉及分泌型 SF01-SF13 蛋白的使用、编码这些蛋白的多核苷酸的使用及其效应物/调节剂在诊断、研究、预防和治疗胰腺疾病（如糖尿病）、肥胖和/或代谢综合征中的使用，以及在胰腺组织等组织再生中的使用。
• MNK KINASE PROTEINS AND DIABETES
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2277552A1

  公开（公告）日：2011-01-26

  The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and e ncode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

  本发明公开了调节能量平衡、甘油三酯代谢和/或有助于膜稳定性和/或细胞器功能的Mnk同源蛋白质，以及识别和编码本发明公开的蛋白质的多核苷酸。本发明还涉及将这些序列用于诊断、研究、预防和治疗与体重调节和产热有关的疾病和失调，例如但不限于代谢性疾病，如肥胖，以及相关失调，如饮食失调、恶病质、糖尿病、高血压、冠心病、高胆固醇血症、血脂异常、骨关节炎、胆结石和睡眠呼吸暂停，以及与 ROS 防御有关的疾病，如糖尿病、神经退行性疾病和癌症，如生殖器官癌症。如生殖器官癌症等。
• Use of DG177 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
  申请人：DeveloGen Aktiengesellschaft

  公开号：EP2289908A1

  公开（公告）日：2011-03-02

  The present invention discloses proteins secreted by the developing pancreas, and polynucleotides, which identify and encode these proteins. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of pancreatic diseases (e.g. diabetes), obesity, and/or metabolic syndrome.

  本发明公开了发育中的胰腺分泌的蛋白质，以及识别和编码这些蛋白质的多核苷酸。本发明还涉及将这些序列用于诊断、研究、预防和治疗胰腺疾病（如糖尿病）、肥胖症和/或代谢综合征。