1,4,7-三氨基庚烷 | 1985-81-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,4,7-三氨基庚烷
• 英文名称: N-bis(3-aminopropyl)methylamine
• 英文别名: bis-(3-aminopropyl)-methylamine；1,4,7-Triaminoheptane；heptane-1,4,7-triamine
• CAS: 1985-81-5
• 化学式: C₇H₁₉N₃
• mdl: MFCD19207188
• 分子量: 145.248
• InChiKey: GDRJDUSGGPSMEI-UHFFFAOYSA-N

物化性质

• 沸点：
  305.4±10.0 °C(Predicted)
• 密度：
  0.934±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  78.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 1,4,7-三氨基庚烷 以 苯酚 为溶剂， 反应 24.0h， 以79%的产率得到N1-(3-aminopropyl)-N3-(7-methoxybenzofuro[3,2-b]quinolin-11-yl)-N1-methylpropane-1,3 -diamine
  参考文献：
  名称：

  Synthesis and evaluation of new BODIPY-benzofuroquinoline conjugates for sensitive and selective DNA detection

  摘要：

  The sensitive and selective detection of nucleic acids is important for basic research and many applied fields. Herein, a series of new BODIPY-benzofuroquinoline conjugates were designed, synthesized and evaluated as DNA intercalating dyes. All compounds were characterized by using H-1, C-13 NMR, IR, UV-Vis and fluorescence spectroscopy, and DNA binding properties of these conjugates to calf thymus DNA were studied by using fluorescence titration, UV titration, isothermal titration calorimetry and CD analysis. Significant enhancement of the fluorescent quantum yield was observed for all the conjugates in the presence of calf thymus DNA, and one compound showed excellent sensitivity and selectivity offering its potential application as a DNA specific fluorescent probe. Our results showed that these conjugates could intercalate into calf thymus DNA with high binding affinities. The properties of these dyes as fluorescent probes for living cells imaging were also investigated. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2014.03.027

文献信息

• FLUORINATED SULFONATE ESTERS OF ARYL KETONES FOR NON-IONIC PHOTO-ACID GENERATORS
  申请人：International Business Machines Corporation

  公开号：US20180046077A1

  公开（公告）日：2018-02-15

  Non-ionic photo-acid generating (PAG) compounds were prepared that contain an aryl ketone group having a perfluorinated substituent alpha to the ketone carbonyl. The non-polymeric PAGs release a sulfonic acid when exposed to high energy radiation such as deep UV or extreme UV light. The photo-generated sulfonic acid has a low diffusion rate in an exposed resist layer subjected to a post-exposure bake (PEB) at 100° C. to 150° C., resulting in formation of good line patterns after development. At higher temperatures, the PAGs can also undergo a thermal reaction to form a sulfonic acid. The perfluorinated substituent provides improved thermal stability and hydrolytic/nucleophilic stability.

  非离子型光生酸(PAG)化合物被制备出来，它们含有一个含有全氟取代基的芳酮基团，该取代基位于酮羰基的α位置。这些非聚合PAGs在暴露于高能辐射，如深紫外或极紫外光时，会释放出磺酸。在100°C至150°C的后曝光烘烤(PEB)下，光生成的磺酸在暴露的抵抗层中具有较低的扩散速率，从而在开发后形成良好的线条图案。在较高温度下，PAGs也可以通过热反应形成磺酸。全氟取代基提供了改善的热稳定性和水解/亲核稳定性。
• MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF TAXANE-BASED COMPOUNDS
  申请人：Nektar Therapeutics

  公开号：US20160235705A1

  公开（公告）日：2016-08-18

  Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.

  在其他方面，本文提供了紫杉醇类化合物和/或其氟化形式的多臂聚合物前药共轭物。还提供了制备这种共轭物的方法以及给药的方法。在给患者施用后，紫杉醇类化合物被释放。
• METHOD FOR PREPARING A COMPOUND COMPRISING AT LEAST ONE BETA-HYDROXY-URETHANE UNIT AND/OR AT LEAST ONE UPSILON-HYDROXY-URETHANE UNIT
  申请人：Soules Aurélien

  公开号：US20140378648A1

  公开（公告）日：2014-12-25

  The invention relates to a method for preparing a compound comprising at least one β-hydroxy-urethane unit and/or at least one γ-hydroxy-urethane unit, consisting in reacting a compound (A) comprising at least one cyclocarbonate reactive unit with a compound (B) comprising at least one amino reactive unit (—NH2) in the presence of a catalyst. The invention also relates to the use of a catalyst comprising at least one organometallic complex and a co-catalyst chosen from the group of Lewis bases and/or tetra-alkyl ammonium salts, in order to catalyse the method of the invention. The invention relates to the technical field of preparing urethane derivatives.

  该发明涉及一种制备至少含有一个β-羟基脲基和/或至少含有一个γ-羟基脲基的化合物的方法，包括将至少含有一个环碳酸酯反应单元的化合物（A）与至少含有一个氨基反应单元（—NH2）的化合物（B）在催化剂存在下反应。该发明还涉及使用至少含有一个有机金属配合物和从Lewis碱和/或四烷基铵盐组中选择的共催化剂的催化剂，以催化该发明的方法。该发明涉及制备脲基衍生物的技术领域。
• Polyamine-substituted ligands for use as contrast agents
  申请人：Wolf Markus

  公开号：US20070202047A1

  公开（公告）日：2007-08-30

  The present invention relates to a polyamine-substituted ligand for the preparation of a contrast agent derived from a chelating molecule selected from the group consisting of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and diethylentriamine-pentaacetic acid (DTPA), wherein at least one of the carboxylic groups of the chelating molecule is reacted with an amine of formula HNR 1 R 2 to form an amide bond, wherein R 1 , R 2 are independently selected from the group consisting of H; (CH 2 ) n —NR 3 R 4 ; and R 5 ; R 3 , R 4 are independently selected from the group consisting of H; (CH 2 ) m —NR 6 R 7 ; and (CH 2 ) m-1 —CH 3 ; R 6 , R 7 are independently selected from the group consisting of H; and (CH 2 ) o-1 —CH 3 ; n, m, o are independently 2, 3, or 4; R 5 is of formula and optionally at least one of the carboxylic groups of the chelating molecule is further reacted with a monoalkylamine having 1 to 18 carbon atoms to form an amide bond; provided that at least one of R 1 , R 2 is other than H. Furthermore, the invention relates to contrast agents for magnetic resonance imaging (MRI) comprising said ligands and in-vivo diagnostic methods based on MRI using said contrast agents.

  本发明涉及一种用于制备对比剂的聚胺取代配体，所述对比剂源自从1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（DOTA）和二乙烯三胺五乙酸（DTPA）组成的羧基配体中选择的螯合分子，其中所述螯合分子的羧基之一与公式HNR1R2的胺反应形成酰胺键，其中R1、R2独立地选择自H；（CH2）n—NR3R4；和R5；R3、R4独立地选择自H；（CH2）m—NR6R7；和（CH2）m-1—CH3；R6、R7独立地选择自H；和（CH2）o-1—CH3；n、m、o独立地为2、3或4；R5为公式，并且可选地，所述螯合分子的羧基之一进一步与具有1至18个碳原子的单烷基胺反应形成酰胺键；前提是R1、R2中至少一个不是H。此外，本发明涉及包括所述配体的磁共振成像（MRI）对比剂以及基于MRI使用所述对比剂的体内诊断方法。
• Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds
  申请人：Cheng Lin

  公开号：US10736969B2

  公开（公告）日：2020-08-11

  Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of pemetrexed-based compounds. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the pemetrexed-based compound is achieved.

  本文提供了基于多臂聚合物的多肢基于培美曲塞的前药共轭物。同时还提供了制备这种共轭物的方法以及给药的方法。给药给患者后，会实现培美曲塞基化合物的释放。