(1R,2R,6S,7R)-4-propan-2-yl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (1R,2R,6S,7R)-4-propan-2-yl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.25
• InChiKey: CCGKCUKWRHWJSR-AATLWQCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Drug delivery polymers and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10792373B2

  公开（公告）日：2020-10-06

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

  本文描述的是铂基刷臂星型聚合物（Pt-BASPs）或其药物组合物，用于递送铂类制剂，如奥沙利铂。还提供了涉及 Pt-BASPs 或其药物组合物的方法和试剂盒，用于治疗受试者的增殖性疾病，如癌症（如肺癌、头颈癌、食道癌、胃癌、乳腺癌、胰腺癌、结直肠癌、肝癌、肾癌或前列腺癌）。
• DRUG DELIVERY POLYMERS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20190054187A1

  公开（公告）日：2019-02-21

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.