1-(2'-羟乙基)-2,2,6,6-四甲基-4-哌啶醇 | 52722-86-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(2'-羟乙基)-2,2,6,6-四甲基-4-哌啶醇
• 中文别名: 光稳定剂201；光稳定剂HS-201；4-羟基-1-(2-羟乙基)-2,2,6,6-四甲基哌啶；羟乙基四甲基哌啶醇；羟乙基哌啶醇；1-(2`-羟乙基)-2,2,6,6-四甲基-4-哌啶醇；1-(2"-羟乙基)-2,2,6,6-四甲基-4-哌啶醇；HA-201
• 英文名称: N-(2-hydroxyethyl)-2,2,6,6-tetramethyl-4piperidinol
• 英文别名: 1-(2-hydroxyethyl)-4-hydroxy-2,2,6,6-tetramethyl-piperidine；1-(2-hydroxy-ethyl)-2,2,6,6-tetramethyl-piperidin-4-ol；1-(2-hydroxyethyl)-2,2,6,6-tetra-methyl-4-hydroxypiperidine；1-(2'-hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-ol；1-(2-hydroxyethyl)-2,2,6,6-tetramethyl-4-piperidinol；N-(2-hydroxyethyl)-2,2,6,6-tetramethyl-4-piperidinol；1-(2-Hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-ol
• CAS: 52722-86-8
• 化学式: C₁₁H₂₃NO₂
• mdl: MFCD01321174
• 分子量: 201.309
• InChiKey: STEYNUVPFMIUOY-UHFFFAOYSA-N

物化性质

• 熔点：
  180-184°C
• 沸点：
  302.6±22.0 °C(Predicted)
• 密度：
  0.975±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，未有已知危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090
• 安全说明：
  S26,S36/37/39
• 危险性防范说明：
  P261,P273,P305+P351+P338
• 危险性描述：
  H315,H319,H335,H412

SDS

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Section I.Chemical Product and Company Identification
Chemical Name 4-Hydroxy-1-(2-hydroxyethyl)-2,2,6,6-tetramethyl
piperidine
Portland OR
Synonym 1-Piperidineethanol, 4-hydroxy-2,2,6,6-tetramethyl- (CA
INDEX NAME);
1-(2-Hydroxyethyl)-2,2,6,6-tetramethyl-4-piperidinol;
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidineethanol
Chemical Formula C11H23NO
CAS Number 52722-86-8

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Section II. Composition and Information on Ingredients
Chemical Name CAS Number Percent (%) TLV/PEL Toxicology Data
4-Hydroxy-1-(2-hydroxyethyl)-2,2,6,6-tetramethyl 52722-86-8 Min. 98.0 (GC) Not available. Not available.
piperidine

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Section III. Hazards Identification
No specific information is available in our data base regarding the toxic effects of this material for humans. However,
Acute Health Effects
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
this compound.
Chronic Health Effects CARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

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Section IV. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin Contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.

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Section V. Fire and Explosion Data
Not available.
May be combustible at high temperature. Auto-Ignition
Flammability
Flash Points Flammable Limits Not available.
Not available.
These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
Combustion Products
Fire Hazards Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
4-Hydroxy-1-(2-hydroxyethyl)-2,2,6,6-tetramethyl
piperidine

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Section VI. Accidental Release Measures
Spill Cleanup Use a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
Instructions
disposal.

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Section VII. Handling and Storage
Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool
Handling and Storage
place. Avoid excessive heat and light. Do not breathe dust.
Information
Always store away from incompatible compounds such as oxidizing agents.

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Section VIII. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure Limits Not available.

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Section IX. Physical and Chemical Properties
Solid. (White Crystalline Powder) Solubility
Physical state @ 20°C Not available.
Not available.
Specific Gravity
Molecular Weight 201.31 Partition Coefficient Not available.
Boiling Point Not available. Vapor Pressure Not applicable.
186°C (366.8°F) Not available.
Melting Point Vapor Density
Not available. Volatility Not available.
Refractive Index
Not available.
Critical Temperature Not available. Odor
Viscosity Not available. Taste Not available.

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Section X. Stability and Reactivity Data
Stability

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This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability Avoid excessive heat and light.
Incompatibilities
Reactive with oxidizing agents.

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Section XI. Toxicological Information
RTECS Number Not available.
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Toxicity Data Not available.
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Acute Toxic Effects No specific information is available in our data base regarding the toxic effects of this material for humans. However,
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this
compound.

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Section XII. Ecological Information
Not available.
Ecotoxicity
Environmental Fate Not available.
Continued on Next Page
4-Hydroxy-1-(2-hydroxyethyl)-2,2,6,6-tetramethyl
piperidine

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Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

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Section XIV. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
PIN Number
Proper Shipping Name Not applicable.
Not applicable.
Packing Group (PG)
DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.
(EPA)
WHMIS Classification Not controlled under WHMIS (Canada).
On NDSL
(Canada)
EINECS Number (EEC) 258-132-1
EEC Risk Statements Not available.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质
白色结晶粉末，能溶于甲醇、乙醇、苯、甲苯等有机溶剂，也能溶于热水，具有较强的吸潮性。

用途
本品是受阻胺系列光稳定剂及有机合成的重要中间体，并广泛用作受阻胺光稳定剂的主要原料。

反应信息

• 作为反应物：
  描述：

  1-(2'-羟乙基)-2,2,6,6-四甲基-4-哌啶醇 在 乙酸酐 、 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 生成 1-(2-acetoxyethyl)-2,2,6,6-tetramethyl-4-piperidinol
  参考文献：
  名称：

  Peroxide free radical initiators containing hindered amine light

  摘要：

  提供了含过氧化物键和受阻胺类光稳定剂基团自由基的化合物。这些化合物作为聚合引发剂，使受阻胺稳定剂与聚合物化学结合。

  公开号：

  US04822883A1
• 作为产物：
  描述：

  环氧乙烷 、 四甲基哌啶醇 以 异丙醇 、 甲苯 为溶剂， 生成 1-(2'-羟乙基)-2,2,6,6-四甲基-4-哌啶醇
  参考文献：
  名称：

  Substituted piperidin-4-ols

  摘要：

  公开了包含聚合物（尤其是聚烯烃）和少量1,2,2,6,6-五取代吡啶啉-4-醇的稳定化组合物。这些新组合物具有良好的光稳定性。

  公开号：

  US04014887A1

文献信息

• OXIME ESTER PHOTOINITIATORS
  申请人：BASF SE

  公开号：US20180208583A1

  公开（公告）日：2018-07-26

  Compounds of the formulae (I) or (II) wherein X is A is O, S, NR 5 or CR 16 R 17 ; R 1 is for example hydrogen or C 1 -C 20 alkyl R 2 is for example hydrogen, C 1 -C 20 alkyl or C 6 -C 20 aryl R 5 for example is C 1 -C 20 alkyl; R 7 , R 8 , R 9 , R 10 and R 11 for example independently of each other are hydrogen. C 1 -C 20 alkyl, halogen, CN or NO 2 ; Ar 1 is for example unsubstituted or substituted C 6 -C 20 aryl, C 3 -C 20 heteroaryl, C 6 -C 20 aroyl, C 3 -C 20 heteroarylcarbonyl or or Ar 1 is Ar 2 is for example phenylene, all of which are unsubstituted or substituted M is for example unsubstituted or substituted C 1 -C 20 alkylene Y is a direct bond, O, S, NR 5 or CO; Z 1 is for example O or S; Z 2 is a direct bond, O, S or NR 5 ; and Q is CO or a direct bond.

  公式(I)或(II)的化合物 其中 X是 A是O, S, NR 5 或CR 16 R 17 ; R 1 例如是氢或C 1 -C 20 烷基 R 2 例如是氢, C 1 -C 20 烷基或C 6 -C 20 芳基 R 5 例如是C 1 -C 20 烷基; R 7 , R 8 , R 9 , R 10 和R 11 例如彼此独立是氢. C 1 -C 20 烷基, 卤素, CN或NO 2 ; Ar 1 例如是不取代或取代的C 6 -C 20 芳基, C 3 -C 20 杂芳基, C 6 -C 20 芳酰基, C 3 -C 20 杂芳基甲酰基或 或Ar 1 是 Ar 2 例如是苯基, 所有这些都不取代或取代 M例如是不取代或取代的C 1 -C 20 亚烷基 Y是直接键, O, S, NR 5 或CO; Z 1 例如是O或S; Z 2 是直接键, O, S或NR 5 ; 和 Q是CO或直接键。
• [EN] STERICALLY HINDERED AMINE STABILIZERS<br/>[FR] STABILISANTS D'AMINES À ENCOMBREMENT STÉRIQUE
  申请人：BASF SE

  公开号：WO2010142572A1

  公开（公告）日：2010-12-16

  The instant invention pertains to hindered amine compounds having at least two nitrogen atoms with different basicity. One part is substituted on the N-atom by alkoxy moieties and the other part is substituted on the N-atom by a hydroxy-alkyl moiety. These materials are particularly effective in stabilizing polymers, especially thermoplastic polyolefins, against the deleterious effects of oxidative, thermal and actinic radiation. The compounds are also particularly effective in stabilizing acid catalyzed and ambient cured coatings systems.

  这项瞬时发明涉及具有至少两个氮原子且碱度不同的受阻胺化合物。其中一部分在N原子上被烷氧基团取代，另一部分在N原子上被一个羟基-烷基基团取代。这些材料在稳定聚合物方面特别有效，尤其是热塑性聚烯烃，可以抵御氧化、热和光辐射的有害影响。这些化合物在稳定酸催化和环境固化的涂层系统方面也特别有效。
• [EN] LIQUID PHOSPHITE COMPOSITION DERIVED FROM META-CRESOLS<br/>[FR] COMPOSITION LIQUIDE DE PHOSPHITES ISSUE DE MÉTA-CRÉSOLS
  申请人：CHEMTURA CORP

  公开号：WO2011014211A1

  公开（公告）日：2011-02-03

  A composition at least two different phosphites, one of which is derived from an alkylated m-cresol, wherein the composition is a liquid at ambient conditions. The other phosphites may be derived from alkylated cresol, alkylated phenol or other alkylated hydroxyaryl compounds. The cresol may be mono-alkylated or di-alkylated with a C1-C18 alkyl group.

  一种至少含有两种不同亚磷酸盐的组成物，其中一种来自烷基化间甲酚，该组成物在常温常压下为液态。其他亚磷酸盐可以来自烷基化甲酚、烷基化酚或其他烷基化羟基芳香族化合物。甲酚可以是单烷基化或二烷基化，并具有C1-C18烷基基团。
• 4-Formyl amino-n-methylpiperidine derivatives, the use thereof as stabilisers and organic material stabilised therewith
  申请人：——

  公开号：US20030083406A1

  公开（公告）日：2003-05-01

  The present invention relates to 4-formylamino-N-methylpiperidine derivatives of the formula (I) 1 where the variables are as defined in the Description, to a process for preparing these piperidine derivatives, to the use of these piperidine derivatives of the invention, or prepared according to the invention, for stabilizing organic material, in particular for stabilizing plastics or coating materials, and also to the use of these piperidine derivatives of the invention, or prepared according to the invention, as light stabilizers or stabilizers for wood surfaces. The present invention further relates to stabilized organic material which comprises these piperidine derivatives of the invention or prepared according to the invention.

  本发明涉及通式(I)的4-甲酰氨基-N-甲基哌啶衍生物 1 其中变量如说明书中所定义，涉及制备这些哌啶衍生物的方法，涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物用于稳定有机材料，特别是用于稳定塑料或涂料材料，还涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物作为光稳定剂或木材表面的稳定剂的使用。 本发明还涉及包含这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物的稳定有机材料。
• [EN] OXIME ESTER PHOTOINITIATORS<br/>[FR] PHOTOAMORCEURS À BASE D'ESTER D'OXIME
  申请人：BASF SE

  公开号：WO2015036910A1

  公开（公告）日：2015-03-19

  Disclosed are oxime ester compounds which have specific benzo (unsaturated 5-membered ring)-carbonyl group and their use as photoinitiators in photopolymerizable compositions, in particular in photoresist formulations for display applications, e.g. liquid crystal display (LCD), organic light emitting diode (OLED) and touch panel.

  披露的是具有特定苯并（不饱和五元环）-羰基基团的肟酯化合物及其作为光聚合组合物中的光引发剂的使用，特别是在显示应用的抗蚀剂配方中，例如液晶显示（LCD）、有机发光二极管（OLED）和触摸面板。