1-(2,3-二甲基-喹喔啉-6-基)-乙酮 | 100142-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 1-(2,3-二甲基-喹喔啉-6-基)-乙酮
• 英文名称: 1-(2,3-dimethyl-quinoxalin-6-yl)-ethanone
• 英文别名: 1-(2,3-Dimethyl-chinoxalin-6-yl)-aethanon；1-(2,3-Dimethyl-6-quinoxalinyl)ethanone；1-(2,3-dimethylquinoxalin-6-yl)ethanone
• CAS: 100142-30-1
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: CNVMDNAVMWHLRE-UHFFFAOYSA-N

物化性质

• 熔点：
  117-119 °C
• 沸点：
  333.1±37.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2,3-二甲基-喹喔啉-6-基)-乙酮 在 过氧乙酸 作用下， 生成 1-(2,3-dimethyl-1,4-dioxy-quinoxalin-6-yl)-ethanone
  参考文献：
  名称：

  404.喹喔啉N-氧化物。第五部分其他Bz取代的衍生物

  摘要：

  DOI：

  10.1039/jr9560002058
• 作为产物：
  描述：

  4-溴邻苯二胺 在 bis-triphenylphosphine-palladium(II) chloride 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 18.0h， 生成 1-(2,3-二甲基-喹喔啉-6-基)-乙酮
  参考文献：
  名称：

  [EN] PYRAZOLOPYRIDINONE COMPOUNDS
  [FR] COMPOSÉS PYRAZOLOPYRIDINONES

  摘要：

  Disclosed herein is a compound of Formula (I) for activating T cells, promoting T cell proliferation, and/or exhibiting antitumor activity, a method of using the compounds disclosed herein for treating cancer, and a pharmaceutical composition comprising the same.

  公开号：

  WO2023011456A1

文献信息

• Substituierte Chinoxalyl-imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel sowie pharmazeutische Präparate
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0288898A1

  公开（公告）日：1988-11-02

  5-Chinoxalyl-imidazolidin-2,4-dione der Formel I in welcher R¹, R², R³, R⁴ und R⁵ angegebene Bedeutungen haben und deren physiologisch verträgliche Salze und Verfahren zu ihrer Herstellung werden beschrieben. Die Verbindungen hemmen die Aldose-Reduktase und können als Arzneimittel verwendet werden.

  式 I 的 5-喹喔啉基咪唑烷-2,4-二酮 式中 R¹、R²、R³、R⁴ 和 R⁵ 的含义，以及它们的生理耐受盐和制备工艺。这些化合物能抑制醛糖还原酶，可用作医药产品。
• Borsche; Barthenheier, Justus Liebigs Annalen der Chemie, 1942, vol. 553, p. 250,257
  作者：Borsche、Barthenheier

  DOI：——

  日期：——
• Borsche; Barthenheier, Justus Liebigs Annalen der Chemie, 1942, vol. 533, p. 250,257
  作者：Borsche、Barthenheier

  DOI：——

  日期：——
• REACTIVE DYES, THEIR PREPARATION AND THEIR USE
  申请人：Hildebrand Rainer

  公开号：US20110285781A1

  公开（公告）日：2011-11-24

  Reactive dyes of formula wherein R 1 is hydrogen or unsubstituted or substituted C 1 -C 4 alkyl, (R 2 ) s denotes s identical or different substituents from the group halogen, nitro, unsubstituted or halo-substituted C 1 -C 4 alkyl, C 2 -C 4 alkanoylamino, C 1 -C 4 alkylsulfonyl, carbamoyl, sulfamoyl and sulfo, Me is chromium, cobalt or iron, E is a bivalent radical of formula wherein X denotes chlorine or fluorine, T is a fibre-reactive radical of formula —NH—(CH 2 ) 2-3 —SO 2 —Z  (2a), —NH—(CH 2 ) 2-3 —O—(CH 2 ) 2-3 —SO 2 —Z  (2b), (R 3 ) 0-2 denotes from 0 to 2 identical or different substituents from the group halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy and sulfo, Z is vinyl or a —CH 2 —CH 2 —U radical and U is a group that is removable under alkaline conditions, Q is a —CH(Hal)-CH 2 -Hal or —C(Hal)=CH 2 group, s is the number 0, 1, 2 or 3, q is the number 0 or 1, A denotes a bivalent radical of formula wherein R 1 , R 2 , X, T, m, n, q and s are as defined above, R 4 and R 7 denote hydrogen or C 1 -C 4 alkyl, R 5 and R 6 represent, each independently of the other, identical or different substituents from the group hydroxyl, halogen, nitro, unsubstituted or halo-substituted C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkanoylamino, C 1 -C 4 alkylsulfonyl, carbamoyl, sulfamoyl and sulfo, and t and u are each independently of the other the number 0, 1, 2 or 3, are especially suitable for dyeing synthetic polyamide fibre materials and yield dyeings or prints having good wet-fastness properties.
• Reactive Dyes, Their Preparation and Their Use
  申请人：Huntsman International LLC

  公开号：US20150143639A1

  公开（公告）日：2015-05-28

  Reactive dyes of formula (1), wherein Me is chromium, cobalt or iron, R 1 is hydrogen or unsubstituted or substituted C 1 -C 4 alkyl, E is a bivalent radical of formula (1a), (1b) or (1c) wherein X denotes chlorine or fluorine, T is a fibre-reactive radical of formula (2a), (2b), (2c), (2d), (2e), or (2f), (R3)0-2 denotes from 0 to 2 identical or different substituents from the group halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy and sulfo, Z is vinyl or a —CH 2 —CH 2 —U radical and U is a group that is removable under alkaline conditions, Q is a —CH(Hal)-CH 2 -Hal or —C(Hal)=CH 2 group, q is the number 0 or 1, G is a bivalent radical of formula (1d) or (1e) wherein (R 2 )s denotes s identical or different substituents from the group halogen, nitro, unsubstituted or halo-substituted C 1 -C 4 alkyl, C 2 -C 4 alkanoylamino, C 1 -C 4 alkylsulfonyl, carbamoyl, sulfamoyl, sulfo and -E-T, wherein E and T are as defined above, s is the number 0, 1, 2 or 3, A denotes a bivalent radical of formula (3a), (3b) or (3c), wherein R 1 , R 2 , X, T, q and s are as defined above, R 4 and R 7 denote hydrogen, C 1 -C 4 alkyl, —COOH or —COO—C 1 -C 4 alkyl, R 5 and R 6 represent, each independently of the other, identical or different substituents from the group hydroxyl, halogen, nitro, unsubstituted or halo-substituted C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkanoylamino, C 1 -C 4 alkylsulfonyl, carbamoyl, sulfamoyl and sulfo, and t and u are each independently of the other the number 0, 1, 2 or 3, are especially suitable for dyeing synthetic polyamide fibre materials and yield dyeings or prints having good wet-fastness properties.