1-(2-亚甲基-4-苯基-1-氮杂环丁基)乙酮 | 294862-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 中文名称: 1-(2-亚甲基-4-苯基-1-氮杂环丁基)乙酮
• 英文名称: 1-(2-Methylidene-4-phenylazetidin-1-yl)ethan-1-one
• 英文别名: 1-(2-methylidene-4-phenylazetidin-1-yl)ethanone
• CAS: 294862-16-1
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: BKPXAANMOXPTLO-UHFFFAOYSA-N

物化性质

• 沸点：
  330.8±42.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-acetyl-4-phenylazetidin-2-one 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 生成 1-(2-亚甲基-4-苯基-1-氮杂环丁基)乙酮
  参考文献：
  名称：

  The reaction of dimethyltitanocene with N-substituted-β-lactams

  摘要：

  2-Methyleneazetidines have been synthesized and isolated by the reaction of beta-lactams with dimethyltitanocene, followed by chromatography on deactivated silica. Efficient conversion required that the lactam nitrogen be strongly deactivated. Methyl transfer predominated in reactions with phenyl and benzyl on the lactam nitrogen. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00919-9

文献信息

• The reaction of dimethyltitanocene with N-substituted-β-lactams
  作者：Isamir Martı́nez、Amy R Howell

  DOI：10.1016/s0040-4039(00)00919-9

  日期：2000.7

  2-Methyleneazetidines have been synthesized and isolated by the reaction of beta-lactams with dimethyltitanocene, followed by chromatography on deactivated silica. Efficient conversion required that the lactam nitrogen be strongly deactivated. Methyl transfer predominated in reactions with phenyl and benzyl on the lactam nitrogen. (C) 2000 Elsevier Science Ltd. All rights reserved.