5-Iodotubercidin; 4-Amino-5-iodo-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 5-Iodotubercidin; 4-Amino-5-iodo-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
• 英文别名: (2R,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C₁₁H₁₃IN₄O₄
• 分子量: 392.15
• InChiKey: WHSIXKUPQCKWBY-VTFQDDHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• 7-deazapurine nucleosides for therapeutic uses
  申请人：Institute of Organic Chemistry and Biochemistry ASCR, V.V.I.

  公开号：US10294262B2

  公开（公告）日：2019-05-21

  The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.

  本发明提供了式 I 的化合物（其中 R1、R2 和 R3 的值在说明书中定义）及其药学上可接受的盐；或其光学异构体；或光学异构体的混合物，以及包含此类化合物的组合物和利用此类化合物和/或组合物的治疗方法。
• Methods of Treating Hepatitis C Virus Infection
  申请人：Ott Melanie

  公开号：US20110110891A1

  公开（公告）日：2011-05-12

  The present disclosure provides methods of treating a hepatitis C virus infection. The methods generally involve administering to an individual in need thereof an effective amount of an active agent that inhibits a RAS-RAF-MEK-ERK signal transduction pathway.
• NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES
  申请人：Institute of Organic Chemistry and Biochemistry ASCR,V.V.I.

  公开号：US20170240584A1

  公开（公告）日：2017-08-24

  The invention provides compounds of formula I, wherein R 1 , R 2 and R 3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
• ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK
  申请人：NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING

  公开号：US20210338706A1

  公开（公告）日：2021-11-04

  The present invention provides a kind of nucleoside analogue compounds, and a composition comprising the compound and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via the compound or the composition.
• US9624257B2
  申请人：——

  公开号：US9624257B2

  公开（公告）日：2017-04-18