1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethylpyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethylpyrimidine-2,4-dione
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.25
• InChiKey: JCVDICFLPGDHAT-CFCGPWAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  90.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NUCLEOTIDE MIMICS AND THEIR PRODRUGS
  申请人：Biota, Inc.

  公开号：EP1485395A2

  公开（公告）日：2004-12-15
• COMPOSITIONS AND METHODS FOR OPTIMIZING CLEAVAGE OF RNA BY RNASE H
  申请人：Isis Pharmaceuticals, Inc.

  公开号：EP1730309A2

  公开（公告）日：2006-12-13
• RNA SYNTHESIS-PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3'-END
  申请人：ChemGenes Corporation

  公开号：US20150218557A1

  公开（公告）日：2015-08-06

  The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31 P NMR purity greater than 99%. A novel process of reverse 5′→3′ directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
• US5051361A
  申请人：——

  公开号：US5051361A

  公开（公告）日：1991-09-24
• US5213972A
  申请人：——

  公开号：US5213972A

  公开（公告）日：1993-05-25