(E)-3-Methylbutan-2-one N,N-dimethylhydrazone | 19885-66-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (E)-3-Methylbutan-2-one N,N-dimethylhydrazone
• 英文别名: syn(CH3)-Methyl-isopropyl-keton-N,N-dimethyl-hydrazon；N-methyl-N-[(E)-3-methylbutan-2-ylideneamino]methanamine
• CAS: 19885-66-6
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: UDKZYSYLFQAFMI-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-Methylbutan-2-one N,N-dimethylhydrazone 、 苯氧乙酰氯 、 三乙胺 生成 (3S,4R)-1-(dimethylamino)-4-methyl-3-phenoxy-4-propan-2-ylazetidin-2-one
  参考文献：
  名称：

  SHARMA, S. D.;PANDHI, S. B., J. ORG. CHEM., 55,(1990) N, C. 2196-2200

  摘要：

  DOI：
• 作为产物：
  描述：

  偏二甲肼 、 3-甲基-2-丁酮 、 乙醇 生成 (E)-3-Methylbutan-2-one N,N-dimethylhydrazone
  参考文献：
  名称：

  CHELUCCI, GIORGIO;GLADIALI, SERAFINO;MARCHETTI, MAURO, J. HETEROCYCL. CHEM., 25,(1988) N, C. 1761-1765

  摘要：

  DOI：

文献信息

• Synthesis, structure and comparative stability of β-hydrazono, oximino methyl ether and imino boronates
  作者：Richard J. Mears、Helen E. Sailes、John P. Watts、Andrew Whiting

  DOI：10.1039/b004573j

  日期：——

  prepared by the sequential lithiation of the corresponding methyl hydrazone or oxime methyl ether, followed by reaction with an iodomethylboronate ester, typically in the form of the pinacol ester. The resulting products have contrasting hydrolytic stabilities. β-Hydrazono boronates are highly sensitive to intramolecularly catalysed hydrolysis, providing the corresponding β-keto boronates in generally high

  β-羟基和肟基 醚 硼酸盐 通过依次将相应的甲基或肟甲基醚锂化，然后与通常以频哪醇形式的碘甲基硼酸酯反应来制备 酯。所得产物具有相反的水解稳定性。β-羟基硼酸盐 对分子内催化高度敏感 水解，提供相应的β-酮 硼酸盐普遍高产；β-肟基醚 硼酸盐 对...稳定 硅石 凝胶 色谱法并显示出E – Z-异构化的证据。稳定的手性硼酸酯 β-肟基衍生物 醚可以通过二乙醇胺介导的频哪醇通过双酯交换工艺轻松制备酯 交换，然后用同手性的二乙醇胺酯水解-再酯化过程 二醇。β-氨基硼酸盐可以通过相应的β-酮基硼酸酯与α-酮缩合原位生成伯胺，但是结果 亚胺 功能高度水解不稳定，不能以纯净形式分离。
• HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20150274738A1

  公开（公告）日：2015-10-01

  Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase; L 1 represents a linker; and R H represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.

  提供的是公式（I）的双功能小分子或其药学上可接受的盐，其中M代表结合激酶的小有机分子，可以是共价或非共价结合，例如Her3蛋白激酶；L1代表连接物；RH代表疏水基团。公式（I）的一个化合物示例是公式（II）的化合物： 还提供了包含公式（I）或（II）化合物的药物组合物，以及使用这些化合物治疗增殖性疾病的方法。
• TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20150297747A1

  公开（公告）日：2015-10-22

  Provided herein are trioxacarcin-antibody drug conjugates of Formula (A): and pharmaceutically acceptable salts thereof, comprising at least one instance of the group -L 1 -(A-L 2 )a-B attached thereto, wherein a is an integer between 1 and 10, inclusive, L 1 is absent or is a linking group, A is a moiety formed from the reaction of two complimentary groups (X and Y), L 2 is absent or is another linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing these antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin-antibody drug conjugates, novel trioxacarcins without an antibody conjugated thereto, pharmaceutical compositions thereof, and methods of their use and treatment.
• STABILIZED POLYPEPTIDES AND USES THEREOF
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160244494A1

  公开（公告）日：2016-08-25

  The present invention provides inventive stabilized STAT polypeptides, pharmaceutical compositions thereof and methods of making and using inventive stabilized STAT polypeptides.
• METAL ORGANIC FRAMEWORKS COMPRISING A PLURALITY OF SBUS WITH DIFFERENT METAL IONS AND/OR A PLURALITY OF ORGANIC LINKING LIGANDS WITH DIFFERENT FUNCTIONAL GROUPS
  申请人：The Regents of the University of California

  公开号：US20170101429A1

  公开（公告）日：2017-04-13

  The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs comprising different metals or metal ions and/or a plurality of organic linking moieties comprising different functional groups.